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The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors

Chronic myeloid leukemia (CML) is initiated and maintained by the tyrosine kinase BCR-ABL which activates a number of signal transduction pathways, including PI3K/AKT signaling and consequently inactivates FOXO transcription factors. ABL-specific tyrosine kinase inhibitors (TKIs) induce minimal apop...

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Detalles Bibliográficos
Autores principales:	Pellicano, Francesca, Scott, Mary T, Helgason, G Vignir, Hopcroft, Lisa E M, Allan, Elaine K, Aspinall-O'Dea, Mark, Copland, Mhairi, Pierce, Andrew, Huntly, Brian J P, Whetton, Anthony D, Holyoake, Tessa L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Cancer Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282530/ https://www.ncbi.nlm.nih.gov/pubmed/24806995 http://dx.doi.org/10.1002/stem.1748

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