The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells

The unfolded protein response (UPR) is a conserved stress-signaling pathway activated after accumulation of unfolded proteins within the endoplasmic reticulum (ER). Active UPR signaling leads to unconventional, enzymatic splicing of XBP1 mRNA enabling expression of the transcription factor XBP1s to...

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Detalles Bibliográficos
Autores principales: Jurkin, Jennifer, Henkel, Theresa, Nielsen, Anne Færch, Minnich, Martina, Popow, Johannes, Kaufmann, Therese, Heindl, Katrin, Hoffmann, Thomas, Busslinger, Meinrad, Martinez, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282640/
https://www.ncbi.nlm.nih.gov/pubmed/25378478
http://dx.doi.org/10.15252/embj.201490332

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