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Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses

BACKGROUND: Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse transcriptase (RT). However, unlike HIV-1,...

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Detalles Bibliográficos
Autores principales:	Lenzi, Gina M, Domaoal, Robert A, Kim, Dong-Hyun, Schinazi, Raymond F, Kim, Baek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282736/ https://www.ncbi.nlm.nih.gov/pubmed/25524560 http://dx.doi.org/10.1186/s12977-014-0111-y

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