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Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2

Acetyl-CoA carboxylase 2 (ACC2) is an isoform of ACC functioning as a negative regulator of fatty acid β-oxidation. Spot14, a thyroid hormone responsive protein, and Mig12, a Spot14 paralog, have recently been identified as regulators of fatty acid synthesis targeting ACC1, a distinctive subtype of...

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Detalles Bibliográficos
Autores principales: Park, Sungjo, Hwang, In-Wook, Makishima, Yu, Perales-Clemente, Ester, Kato, Tatsuya, Niederländer, Nicolas J, Park, Enoch Y, Terzic, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283044/
https://www.ncbi.nlm.nih.gov/pubmed/24277613
http://dx.doi.org/10.1002/jmr.2313

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