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Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function

Aging, the main risk factor for Parkinson's disease (PD), is associated with increased α–synuclein levels in substantia nigra pars compacta (SNc). Excess α-synuclein spurs Lewy-like pathology and dysregulates the activity of protein phosphatase 2A (PP2A). PP2A dephosphorylates many neuroprotein...

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Detalles Bibliográficos
Autores principales:	Farrell, Kaitlin F, Krishnamachari, Sesha, Villanueva, Ernesto, Lou, Haiyan, Alerte, Tshianda N M, Peet, Eloise, Drolet, Robert E, Perez, Ruth G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283050/ https://www.ncbi.nlm.nih.gov/pubmed/24117685 http://dx.doi.org/10.1111/jnc.12481

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