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Comparison of the effects of two different formulas of fluids in craniotomy patients

BACKGROUND: Intraoperative fluid management of the patients who had undergone neurosurgery presents special challenges for the anesthesiologist. In this study, we aimed to compare the effects of two fluid combinations (half-normal + bicarbonate with saline + Ringer's lactate) on brain relaxatio...

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Autores principales: Attari, Mohammadali, Sane, Shahryar, Bordbar, Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283248/
https://www.ncbi.nlm.nih.gov/pubmed/25590035
http://dx.doi.org/10.4103/2277-9175.146927
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author Attari, Mohammadali
Sane, Shahryar
Bordbar, Akbar
author_facet Attari, Mohammadali
Sane, Shahryar
Bordbar, Akbar
author_sort Attari, Mohammadali
collection PubMed
description BACKGROUND: Intraoperative fluid management of the patients who had undergone neurosurgery presents special challenges for the anesthesiologist. In this study, we aimed to compare the effects of two fluid combinations (half-normal + bicarbonate with saline + Ringer's lactate) on brain relaxation, and acid, base, and hemodynamic balance in patients undergoing elective craniotomy surgery. MATERIALS AND METHODS: This randomized double-blind controlled clinical trial study was done on 50 patients, of age 20–60 years, undergoing craniotomy in Alzahra Hospital in 2012. They were divided in two groups of 25 patients each. In the control group, after the patients received hypertonic saline, normal saline serum and Ringer's lactate was administered, and in the half-normal study group, 80 ml of sodium bicarbonate for every liter of it was added. Arterial blood gas (ABG) was taken before the last suture. Brain relaxation before dura opening was registered. RESULTS: There was no significant difference in heart rate changes (P = 0.054). No significant difference was observed in the mean arterial pressure between the two groups (P = 0.99). Changes in pH, HCO3, and BE were not significantly different (P = 0.99) between the two groups. Urine output in half-normal saline group was significantly higher than in normal saline group. The mean bleeding volume was higher in normal saline group, but was not significantly different (P = 0.54). The mean volume of injected blood was higher in half-normal group with a significant difference (P = 0.54). The injected blood volume mean in half-normal group was higher with no significant difference (P = 0.55). The mean of brain relaxation was not different (P = 0.5). CONCLUSION: These two fluids did not show any significant differences in the studied variables in this research.
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spelling pubmed-42832482015-01-14 Comparison of the effects of two different formulas of fluids in craniotomy patients Attari, Mohammadali Sane, Shahryar Bordbar, Akbar Adv Biomed Res Original Article BACKGROUND: Intraoperative fluid management of the patients who had undergone neurosurgery presents special challenges for the anesthesiologist. In this study, we aimed to compare the effects of two fluid combinations (half-normal + bicarbonate with saline + Ringer's lactate) on brain relaxation, and acid, base, and hemodynamic balance in patients undergoing elective craniotomy surgery. MATERIALS AND METHODS: This randomized double-blind controlled clinical trial study was done on 50 patients, of age 20–60 years, undergoing craniotomy in Alzahra Hospital in 2012. They were divided in two groups of 25 patients each. In the control group, after the patients received hypertonic saline, normal saline serum and Ringer's lactate was administered, and in the half-normal study group, 80 ml of sodium bicarbonate for every liter of it was added. Arterial blood gas (ABG) was taken before the last suture. Brain relaxation before dura opening was registered. RESULTS: There was no significant difference in heart rate changes (P = 0.054). No significant difference was observed in the mean arterial pressure between the two groups (P = 0.99). Changes in pH, HCO3, and BE were not significantly different (P = 0.99) between the two groups. Urine output in half-normal saline group was significantly higher than in normal saline group. The mean bleeding volume was higher in normal saline group, but was not significantly different (P = 0.54). The mean volume of injected blood was higher in half-normal group with a significant difference (P = 0.54). The injected blood volume mean in half-normal group was higher with no significant difference (P = 0.55). The mean of brain relaxation was not different (P = 0.5). CONCLUSION: These two fluids did not show any significant differences in the studied variables in this research. Medknow Publications & Media Pvt Ltd 2014-12-12 /pmc/articles/PMC4283248/ /pubmed/25590035 http://dx.doi.org/10.4103/2277-9175.146927 Text en Copyright: © 2014 Attari M. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Attari, Mohammadali
Sane, Shahryar
Bordbar, Akbar
Comparison of the effects of two different formulas of fluids in craniotomy patients
title Comparison of the effects of two different formulas of fluids in craniotomy patients
title_full Comparison of the effects of two different formulas of fluids in craniotomy patients
title_fullStr Comparison of the effects of two different formulas of fluids in craniotomy patients
title_full_unstemmed Comparison of the effects of two different formulas of fluids in craniotomy patients
title_short Comparison of the effects of two different formulas of fluids in craniotomy patients
title_sort comparison of the effects of two different formulas of fluids in craniotomy patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283248/
https://www.ncbi.nlm.nih.gov/pubmed/25590035
http://dx.doi.org/10.4103/2277-9175.146927
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