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Annual Decline in Pentraxin 3 Is a Risk of Vascular Access Troubles in Hemodialysis Patients
Pentraxin 3 (PTX3), a multifunctional modulator of the innate immunoinflammatory response, is higher in patients undergoing hemodialysis than healthy control. Our study focused on annual change in PTX3 levels in patients with chronic hemodialysis, because regularly undergoing hemodialysis for many y...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283416/ https://www.ncbi.nlm.nih.gov/pubmed/25587447 http://dx.doi.org/10.1155/2014/297954 |
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author | Nagai, Kei Ueda, Atsushi Saito, Chie Zempo-Miyaki, Asako Yamagata, Kunihiro |
author_facet | Nagai, Kei Ueda, Atsushi Saito, Chie Zempo-Miyaki, Asako Yamagata, Kunihiro |
author_sort | Nagai, Kei |
collection | PubMed |
description | Pentraxin 3 (PTX3), a multifunctional modulator of the innate immunoinflammatory response, is higher in patients undergoing hemodialysis than healthy control. Our study focused on annual change in PTX3 levels in patients with chronic hemodialysis, because regularly undergoing hemodialysis for many years modifies vascular inflammatory status. To demonstrate whether annual change in PTX3 is associated with vascular events, we measured blood levels of pentraxins (PTX3 and high-sensitivity C-reactive protein (hsCRP)) at baseline and in the next year in 76 hemodialysis patients and observed 20 patients with vascular access troubles during follow-up years. The annual decline in PTX3, but not hsCRP, is a significant risk of the incidence of vascular access trouble that is a critical and specific complication for hemodialysis patients (hazard ratio; 0.732 per +1 ng/mL/year in PTX3, (*) P = 0.039). This study is the first to focus on the annual change of pentraxins in a hemodialysis cohort. |
format | Online Article Text |
id | pubmed-4283416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42834162015-01-13 Annual Decline in Pentraxin 3 Is a Risk of Vascular Access Troubles in Hemodialysis Patients Nagai, Kei Ueda, Atsushi Saito, Chie Zempo-Miyaki, Asako Yamagata, Kunihiro Int J Nephrol Research Article Pentraxin 3 (PTX3), a multifunctional modulator of the innate immunoinflammatory response, is higher in patients undergoing hemodialysis than healthy control. Our study focused on annual change in PTX3 levels in patients with chronic hemodialysis, because regularly undergoing hemodialysis for many years modifies vascular inflammatory status. To demonstrate whether annual change in PTX3 is associated with vascular events, we measured blood levels of pentraxins (PTX3 and high-sensitivity C-reactive protein (hsCRP)) at baseline and in the next year in 76 hemodialysis patients and observed 20 patients with vascular access troubles during follow-up years. The annual decline in PTX3, but not hsCRP, is a significant risk of the incidence of vascular access trouble that is a critical and specific complication for hemodialysis patients (hazard ratio; 0.732 per +1 ng/mL/year in PTX3, (*) P = 0.039). This study is the first to focus on the annual change of pentraxins in a hemodialysis cohort. Hindawi Publishing Corporation 2014 2014-12-22 /pmc/articles/PMC4283416/ /pubmed/25587447 http://dx.doi.org/10.1155/2014/297954 Text en Copyright © 2014 Kei Nagai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nagai, Kei Ueda, Atsushi Saito, Chie Zempo-Miyaki, Asako Yamagata, Kunihiro Annual Decline in Pentraxin 3 Is a Risk of Vascular Access Troubles in Hemodialysis Patients |
title | Annual Decline in Pentraxin 3 Is a Risk of Vascular Access Troubles in Hemodialysis Patients |
title_full | Annual Decline in Pentraxin 3 Is a Risk of Vascular Access Troubles in Hemodialysis Patients |
title_fullStr | Annual Decline in Pentraxin 3 Is a Risk of Vascular Access Troubles in Hemodialysis Patients |
title_full_unstemmed | Annual Decline in Pentraxin 3 Is a Risk of Vascular Access Troubles in Hemodialysis Patients |
title_short | Annual Decline in Pentraxin 3 Is a Risk of Vascular Access Troubles in Hemodialysis Patients |
title_sort | annual decline in pentraxin 3 is a risk of vascular access troubles in hemodialysis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283416/ https://www.ncbi.nlm.nih.gov/pubmed/25587447 http://dx.doi.org/10.1155/2014/297954 |
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