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Targets, models and challenges in osteoarthritis research

Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most common diseases worldwide. Its prevalence and severity are increasing owing to aging of the population, but treatment options remain largely limited to painkillers and anti-inflammatory drugs, which only pr...

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Autores principales: Thysen, Sarah, Luyten, Frank P., Lories, Rik J. U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283647/
https://www.ncbi.nlm.nih.gov/pubmed/25561745
http://dx.doi.org/10.1242/dmm.016881
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author Thysen, Sarah
Luyten, Frank P.
Lories, Rik J. U.
author_facet Thysen, Sarah
Luyten, Frank P.
Lories, Rik J. U.
author_sort Thysen, Sarah
collection PubMed
description Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most common diseases worldwide. Its prevalence and severity are increasing owing to aging of the population, but treatment options remain largely limited to painkillers and anti-inflammatory drugs, which only provide symptomatic relief. In the late stages of the disease, surgical interventions are often necessary to partially restore joint function. Although the focus of osteoarthritis research has been originally on the articular cartilage, novel findings are now pointing to osteoarthritis as a disease of the whole joint, in which failure of different joint components can occur. In this Review, we summarize recent progress in the field, including data from novel ‘omics’ technologies and from a number of preclinical and clinical trials. We describe different in vitro and in vivo systems that can be used to study molecules, pathways and cells that are involved in osteoarthritis. We illustrate that a comprehensive and multisystem approach is necessary to understand the complexity and heterogeneity of the disease and to better guide the development of novel therapeutic strategies for osteoarthritis.
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spelling pubmed-42836472015-01-06 Targets, models and challenges in osteoarthritis research Thysen, Sarah Luyten, Frank P. Lories, Rik J. U. Dis Model Mech Review Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most common diseases worldwide. Its prevalence and severity are increasing owing to aging of the population, but treatment options remain largely limited to painkillers and anti-inflammatory drugs, which only provide symptomatic relief. In the late stages of the disease, surgical interventions are often necessary to partially restore joint function. Although the focus of osteoarthritis research has been originally on the articular cartilage, novel findings are now pointing to osteoarthritis as a disease of the whole joint, in which failure of different joint components can occur. In this Review, we summarize recent progress in the field, including data from novel ‘omics’ technologies and from a number of preclinical and clinical trials. We describe different in vitro and in vivo systems that can be used to study molecules, pathways and cells that are involved in osteoarthritis. We illustrate that a comprehensive and multisystem approach is necessary to understand the complexity and heterogeneity of the disease and to better guide the development of novel therapeutic strategies for osteoarthritis. The Company of Biologists Limited 2015-01 /pmc/articles/PMC4283647/ /pubmed/25561745 http://dx.doi.org/10.1242/dmm.016881 Text en © 2015. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Thysen, Sarah
Luyten, Frank P.
Lories, Rik J. U.
Targets, models and challenges in osteoarthritis research
title Targets, models and challenges in osteoarthritis research
title_full Targets, models and challenges in osteoarthritis research
title_fullStr Targets, models and challenges in osteoarthritis research
title_full_unstemmed Targets, models and challenges in osteoarthritis research
title_short Targets, models and challenges in osteoarthritis research
title_sort targets, models and challenges in osteoarthritis research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283647/
https://www.ncbi.nlm.nih.gov/pubmed/25561745
http://dx.doi.org/10.1242/dmm.016881
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