Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo

BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease characterised by cartilage degradation and chondrocyte hypertrophy. A recent study showed that Rac1 promoted expression of MMP13 and chondrocyte hypertrophy within the growth plate. These findings warrant further investigations on the r...

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Detalles Bibliográficos
Autores principales: Zhu, Shouan, Lu, Ping, Liu, Huanhuan, Chen, Pengfei, Wu, Yan, Wang, Yanyan, Sun, Heng, Zhang, Xiaolei, Xia, Qingqing, Heng, Boon Chin, Zhou, Yiting, Ouyang, Hong Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283675/
https://www.ncbi.nlm.nih.gov/pubmed/24257023
http://dx.doi.org/10.1136/annrheumdis-2013-203901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283675/
https://www.ncbi.nlm.nih.gov/pubmed/24257023
http://dx.doi.org/10.1136/annrheumdis-2013-203901

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