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Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo

BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease characterised by cartilage degradation and chondrocyte hypertrophy. A recent study showed that Rac1 promoted expression of MMP13 and chondrocyte hypertrophy within the growth plate. These findings warrant further investigations on the r...

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Detalles Bibliográficos
Autores principales:	Zhu, Shouan, Lu, Ping, Liu, Huanhuan, Chen, Pengfei, Wu, Yan, Wang, Yanyan, Sun, Heng, Zhang, Xiaolei, Xia, Qingqing, Heng, Boon Chin, Zhou, Yiting, Ouyang, Hong Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2015
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283675/ https://www.ncbi.nlm.nih.gov/pubmed/24257023 http://dx.doi.org/10.1136/annrheumdis-2013-203901

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