AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis

OBJECTIVES: Synovial fluid glutamate concentrations increase in arthritis. Activation of kainate (KA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. We hypothesised that AMPA an...

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Detalles Bibliográficos
Autores principales: Bonnet, Cleo S, Williams, Anwen S, Gilbert, Sophie J, Harvey, Ann K, Evans, Bronwen A, Mason, Deborah J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283694/
https://www.ncbi.nlm.nih.gov/pubmed/24130267
http://dx.doi.org/10.1136/annrheumdis-2013-203670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283694/
https://www.ncbi.nlm.nih.gov/pubmed/24130267
http://dx.doi.org/10.1136/annrheumdis-2013-203670

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