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Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin

We describe the development and scale-up of a novel two chain immunotoxin refolding process. This work provides a case study comparing a clinical manufacturing process and the commercial process developed to replace it. While the clinical process produced high quality material, it suffered from low...

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Detalles Bibliográficos
Autores principales:	Linke, Thomas, Aspelund, Matthew T, Thompson, Christopher, Xi, Guoling, Fulton, Andrew, Wendeler, Michaela, Pabst, Timothy M, Wang, Xiangyang, Wang, William K, Ram, Kripa, Hunter, Alan K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Bioseparations and Downstream Processing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283723/ https://www.ncbi.nlm.nih.gov/pubmed/25139260 http://dx.doi.org/10.1002/btpr.1983

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