Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling

Fibroblast growth factor (FGF2) regulates endothelial and melanoma cell migration. The binding of FGF2 to its receptor requires N-sulfated heparan sulfate (HS) glycosamine. We have previously reported that Epac1, an exchange protein activated by cAMP, increases N-sulfation of HS in melanoma. Therefo...

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Detalles Bibliográficos
Autores principales: Baljinnyam, Erdene, Umemura, Masanari, Chuang, Christine, De Lorenzo, Mariana S, Iwatsubo, Mizuka, Chen, Suzie, Goydos, James S, Ishikawa, Yoshihiro, Whitelock, John M, Iwatsubo, Kousaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283731/
https://www.ncbi.nlm.nih.gov/pubmed/24725364
http://dx.doi.org/10.1111/pcmr.12250

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