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The impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure
INTRODUCTION: It is well known that the function of kidneys is impaired with age. AIM: The purpose of the study was to evaluate whether chronic kidney disease (CKD) is a predictor for 1-year follow-up mortality among hospitalized chronic heart failure (CHF) patients aged 80+. MATERIAL AND METHODS: T...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283880/ https://www.ncbi.nlm.nih.gov/pubmed/26336438 http://dx.doi.org/10.5114/kitp.2014.45680 |
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author | Cichocka-Radwan, Anna Ciurus, Tomasz Lelonek, Malgorzata |
author_facet | Cichocka-Radwan, Anna Ciurus, Tomasz Lelonek, Malgorzata |
author_sort | Cichocka-Radwan, Anna |
collection | PubMed |
description | INTRODUCTION: It is well known that the function of kidneys is impaired with age. AIM: The purpose of the study was to evaluate whether chronic kidney disease (CKD) is a predictor for 1-year follow-up mortality among hospitalized chronic heart failure (CHF) patients aged 80+. MATERIAL AND METHODS: The study included 141 consecutive patients aged 80-92 (mean: 82.4 years, 44.7% men). The prospective analysis contains 61 variables with glomerular filtration rate (GFR) and the occurrence of death at the 1-year follow-up. Patients were divided and analyzed depending on GFR. RESULTS: Chronic kidney disease defined as estimated GFR < 60 ml/min/1.73 m(2) was recorded in 93 patients (66%). A relationship with GFR < 60 was found for older age (p = 0.0001), lower body mass index – BMI (p = 0.003), more advanced NYHA class III (p = 0.007), higher concentrations of N-terminal probrain natriuretic peptide – NT-proBNP (p = 0.023), lower hemoglobin (p = 0.0004) and LVEF (p = 0.005), longer hospitalization (p = 0.005), more frequent ventricular blocks in ECG (p = 0.017) and rarely performed coronary angiography (p = 0.021). In turn, GFR < 30 ml/min/1.73 m(2) was recorded in 14 patients (9.9%). Similar relationships as in GFR < 60 were found for GFR < 30 and additionally higher concentrations of high-sensitivity C-reactive protein (hsCRP) (p = 0.003), D-dimer (p = 0.002) and more frequent dyslipidemia (p = 0.004) and left main coronary artery disease (p = 0.007). Annual mortality for the total population was 14.2% (n = 20) and was higher (16.1%) if GFR was < 60 and even more (21.4%) in GFR < 30. However, the relationship between deaths and GFR was not statistically significant (for GFR < 60, p = 0.505 and GFR < 30, p = 0.547). CONCLUSIONS: Annual mortality in the patients 80+ who suffered from CHF was high but not statistically significantly associated with CKD. |
format | Online Article Text |
id | pubmed-4283880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-42838802015-09-02 The impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure Cichocka-Radwan, Anna Ciurus, Tomasz Lelonek, Malgorzata Kardiochir Torakochirurgia Pol Heart and Lung Failure, Transplantology INTRODUCTION: It is well known that the function of kidneys is impaired with age. AIM: The purpose of the study was to evaluate whether chronic kidney disease (CKD) is a predictor for 1-year follow-up mortality among hospitalized chronic heart failure (CHF) patients aged 80+. MATERIAL AND METHODS: The study included 141 consecutive patients aged 80-92 (mean: 82.4 years, 44.7% men). The prospective analysis contains 61 variables with glomerular filtration rate (GFR) and the occurrence of death at the 1-year follow-up. Patients were divided and analyzed depending on GFR. RESULTS: Chronic kidney disease defined as estimated GFR < 60 ml/min/1.73 m(2) was recorded in 93 patients (66%). A relationship with GFR < 60 was found for older age (p = 0.0001), lower body mass index – BMI (p = 0.003), more advanced NYHA class III (p = 0.007), higher concentrations of N-terminal probrain natriuretic peptide – NT-proBNP (p = 0.023), lower hemoglobin (p = 0.0004) and LVEF (p = 0.005), longer hospitalization (p = 0.005), more frequent ventricular blocks in ECG (p = 0.017) and rarely performed coronary angiography (p = 0.021). In turn, GFR < 30 ml/min/1.73 m(2) was recorded in 14 patients (9.9%). Similar relationships as in GFR < 60 were found for GFR < 30 and additionally higher concentrations of high-sensitivity C-reactive protein (hsCRP) (p = 0.003), D-dimer (p = 0.002) and more frequent dyslipidemia (p = 0.004) and left main coronary artery disease (p = 0.007). Annual mortality for the total population was 14.2% (n = 20) and was higher (16.1%) if GFR was < 60 and even more (21.4%) in GFR < 30. However, the relationship between deaths and GFR was not statistically significant (for GFR < 60, p = 0.505 and GFR < 30, p = 0.547). CONCLUSIONS: Annual mortality in the patients 80+ who suffered from CHF was high but not statistically significantly associated with CKD. Termedia Publishing House 2014-09-28 2014-09 /pmc/articles/PMC4283880/ /pubmed/26336438 http://dx.doi.org/10.5114/kitp.2014.45680 Text en Copyright © 2014 http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Heart and Lung Failure, Transplantology Cichocka-Radwan, Anna Ciurus, Tomasz Lelonek, Malgorzata The impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure |
title | The impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure |
title_full | The impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure |
title_fullStr | The impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure |
title_full_unstemmed | The impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure |
title_short | The impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure |
title_sort | impact of chronic kidney disease on the annual prognosis in patients 80+ years old suffering from chronic heart failure |
topic | Heart and Lung Failure, Transplantology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283880/ https://www.ncbi.nlm.nih.gov/pubmed/26336438 http://dx.doi.org/10.5114/kitp.2014.45680 |
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