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The Rate-Limiting Step of O(2) Activation in the α-Ketoglutarate Oxygenase Factor Inhibiting Hypoxia Inducible Factor
[Image: see text] Factor inhibiting HIF (FIH) is a cellular O(2)-sensing enzyme, which hydroxylates the hypoxia inducible factor-1α. Previously reported inverse solvent kinetic isotope effects indicated that FIH limits its overall turnover through an O(2) activation step ( J. A. Hangasky, E. Saban,...
Autores principales: | Hangasky, John A., Gandhi, Hasand, Valliere, Meaghan A., Ostrom, Nathaniel E., Knapp, Michael J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283935/ https://www.ncbi.nlm.nih.gov/pubmed/25423620 http://dx.doi.org/10.1021/bi501246v |
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