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The Proximal J Kappa Germline-Transcript Promoter Facilitates Receptor Editing through Control of Ordered Recombination

V(D)J recombination creates antibody light chain diversity by joining a Vκ gene segment with one of four Jκ segments. Two Jκ germline-transcript (GT) promoters control Vκ-Jκ joining, but the mechanisms that govern Jκ choice are unclear. Here, we show in gene-targeted mice that the proximal GT promot...

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Detalles Bibliográficos
Autores principales:	Vettermann, Christian, Timblin, Greg A., Lim, Vivian, Lai, Ernest C., Schlissel, Mark S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283955/ https://www.ncbi.nlm.nih.gov/pubmed/25559567 http://dx.doi.org/10.1371/journal.pone.0113824

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