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USL255 extended-release topiramate: Dose-proportional pharmacokinetics and tolerability in healthy volunteers

OBJECTIVE: Evaluate the pharmacokinetics (PK), safety, and tolerability of single doses of once-daily USL255, Qudexy XR (topiramate) extended-release capsules, over a wide dosing range. METHODS: Two single-dose, phase I studies in healthy adults were used to evaluate the PK profile and maximum toler...

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Detalles Bibliográficos
Autores principales:	Clark, Annie M, Halvorsen, Mark B, Braun, Tricia L, Johnson, Krista M, Cloyd, James C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Full-Length Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283972/ https://www.ncbi.nlm.nih.gov/pubmed/24861853 http://dx.doi.org/10.1111/epi.12654

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