Cargando…

Long-term safety of perampanel and seizure outcomes in refractory partial-onset seizures and secondarily generalized seizures: Results from phase III extension study 307

OBJECTIVE: To evaluate safety, tolerability, seizure frequency, and regional variations in treatment responses with the AMPA antagonist, perampanel, in a large extension study during up to 3 years of treatment. METHODS: Patients ≥12 years old with partial-onset seizures despite treatment with 1–3 an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krauss, Gregory L, Perucca, Emilio, Ben-Menachem, Elinor, Kwan, Patrick, Shih, Jerry J, Clément, Jean-François, Wang, Xuefeng, Bagul, Makarand, Gee, Michelle, Zhu, Jin, Squillacote, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Full-Length Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283992/ https://www.ncbi.nlm.nih.gov/pubmed/24867391 http://dx.doi.org/10.1111/epi.12643

Ejemplares similares

Cognitive effects of adjunctive perampanel for partial‐onset seizures: A randomized trial
por: Meador, Kimford J., et al.
Publicado: (2016)

Assessment of the long‐term efficacy and safety of adjunctive perampanel in tonic‐clonic seizures: Analysis of four open‐label extension studies
por: Rektor, Ivan, et al.
Publicado: (2020)

Functional Connectivity of the Corpus Callosum in Epilepsy Patients with Secondarily Generalized Seizures
por: Peng, Syu-Jyun, et al.
Publicado: (2017)

Open‐label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to <12 years) with inadequately controlled focal seizures or generalized tonic‐clonic seizures
por: Fogarasi, Andras, et al.
Publicado: (2020)

Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures
por: Peng, Syu-Jyun, et al.
Publicado: (2016)

Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies
por: Kwan, Patrick, et al.
Publicado: (2017)

Efficacy and safety of adjunctive perampanel in patients with focal seizures or generalized tonic‐clonic seizures: Post hoc analysis of Phase II and Phase III double‐blind and open‐label extension studies in India
por: Mehndiratta, Man M., et al.
Publicado: (2021)

Newly diagnosed seizures assessed at two established first seizure clinics: Clinic characteristics, investigations, and findings over 11 years
por: McIntosh, Anne M., et al.
Publicado: (2021)

Dissociation of spontaneous seizures and brainstem seizure thresholds in mice exposed to eight flurothyl‐induced generalized seizures
por: Kadiyala, Sridhar B., et al.
Publicado: (2016)

Perampanel-Induced, New-Onset Thrombocytopenia in a Patient With Refractory Seizures: A Case Report
por: Almuhanna, Rakan A, et al.
Publicado: (2023)

Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy: A randomized trial
por: French, Jacqueline A., et al.
Publicado: (2015)

Profile of perampanel and its potential in the treatment of partial onset seizures
por: Rheims, Sylvain, et al.
Publicado: (2013)

Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel
por: Dirani, Maya, et al.
Publicado: (2014)

Seizure remission and improvement of neurological function in sialidosis with perampanel therapy
por: Hu, Su-Ching, et al.
Publicado: (2018)

Sustained seizure remission on perampanel in progressive myoclonic epilepsy (Lafora disease)()
por: Schorlemmer, Kathrin, et al.
Publicado: (2013)

Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy
por: Faulkner, Michele A
Publicado: (2017)

The Effectiveness of Perampanel for Myoclonic Seizures in Down Syndrome with Isodicentric Chromosome 21
por: Obara, Koji, et al.
Publicado: (2020)

Perampanel Reduces Hyperthermia-Induced Seizures in Dravet Syndrome Mouse Model
por: Ho, Shih-Yin, et al.
Publicado: (2021)

Perioperative perampanel administration for early seizure prophylaxis in brain tumor patients
por: Kusakabe, Kosuke, et al.
Publicado: (2023)

Exacerbation of Repetitive Falls Due to Atonic Seizures Following Perampanel Administration
por: Maeda, Akiko, et al.
Publicado: (2023)

Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures
por: Franz, David N., et al.
Publicado: (2018)

Anti-Seizure Activity of 1-Adamantane Carboxylic Acid in Common Experimental Seizure Models: Role of Benzodiazepine-GABA(A) Receptors
por: Ghanbari, Elham, et al.
Publicado: (2021)

The efficacy and safety of adjunctive perampanel for the treatment of refractory focal‐onset seizures in patients with epilepsy: A meta‐analysis
por: Li, Yiming, et al.
Publicado: (2022)

Visual seizure annotation and automated seizure detection using behind‐the‐ear electroencephalographic channels
por: Vandecasteele, Kaat, et al.
Publicado: (2020)

Trait and state interoceptive abnormalities are associated with dissociation and seizure frequency in patients with functional seizures
por: Koreki, Akihiro, et al.
Publicado: (2020)

Clinical efficacy of perampanel for partial-onset and primary generalized tonic–clonic seizures
por: Besag, Frank MC, et al.
Publicado: (2016)

ACT-13 RESPONSE TO SEIZURE AND TUMOR-PROGRESSION BY TREATMENT WITH PERAMPANEL IN PATIENTS WITH GLIOMAS
por: Izumoto, Shuichi, et al.
Publicado: (2019)

First add‐on perampanel for focal‐onset seizures: An open‐label, prospective study
por: Kim, Ji Hyun, et al.
Publicado: (2019)

Multimodal, automated detection of nocturnal motor seizures at home: Is a reliable seizure detector feasible?
por: van Andel, Judith, et al.
Publicado: (2017)

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models
por: Patra, Pabitra Hriday, et al.
Publicado: (2018)

Perampanel in the management of partial-onset seizures: a review of safety, efficacy, and patient acceptability
por: Schulze-Bonhage, Andreas, et al.
Publicado: (2015)

An Evidence-Based Review On The Use Of Perampanel For The Treatment Of Focal-Onset Seizures In Pediatric Patients
por: Dozières-Puyravel, Blandine, et al.
Publicado: (2019)

New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System
por: Perucca, Emilio, et al.
Publicado: (2023)

Driving a motor vehicle and psychogenic nonepileptic seizures: ILAE Report by the Task Force on Psychogenic Nonepileptic Seizures
por: Asadi‐Pooya, Ali A., et al.
Publicado: (2020)

Time to exceed pre‐randomization monthly seizure count for perampanel in participants with primary generalized tonic–clonic seizures: A potential clinical end point
por: Kerr, Wesley T., et al.
Publicado: (2022)

Widespread EEG Changes Precede Focal Seizures
por: Perucca, Piero, et al.
Publicado: (2013)

Insulinoma presenting as refractory seizure disorder
por: Correia, Pamela, et al.
Publicado: (2012)

Cefoperazone-Sulbactam Associated Refractory Seizures
por: Chovatiya, Harshad, et al.
Publicado: (2021)

Long‐term open‐label perampanel: Generalized tonic–clonic seizures in idiopathic generalized epilepsy
por: French, Jacqueline A., et al.
Publicado: (2022)

Efficacy and Safety of Perampanel in Children with Drug-Resistant Focal-Onset Seizures: A Retrospective Review
por: Elmardenly, Ahmed, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6mr3q364n68bg6ogvekc83nkfj