Cargando…

Differential CTLA-4 expression in human CD4(+) versus CD8(+) T cells is associated with increased NFAT1 and inhibition of CD4(+) proliferation

CTLA-4 is a costimulatory molecule that negatively regulates T cell activation. Originally identified in murine CD8(+) T cells, it has been found to be rapidly induced on human T cells. Furthermore, CTLA-4 is expressed on regulatory T cells (T(regs)). Clinically, targeting CTLA-4 has clinical utilit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, Derek V., Gibson, Heather M., Aufiero, Barbara M., Wilson, Adam J., Hafner, Mikehl S., Mi, Qing-Sheng, Wong, Henry K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284071/ https://www.ncbi.nlm.nih.gov/pubmed/24173147 http://dx.doi.org/10.1038/gene.2013.57

Ejemplares similares

Increased percentage of apoptotic and CTLA-4 (CD152) expressing cells in CD4(+)/CD8(+) cells in COVID-19 patients
por: Zahran, Asmaa M., et al.
Publicado: (2022)

CD152 (CTLA-4) Determines CD4 T Cell Migration In Vitro and In Vivo
por: Knieke, Karin, et al.
Publicado: (2009)

TGF-β and IL-10 Production by HIV-Specific CD8+ T Cells Is Regulated by CTLA-4 Signaling on CD4+ T Cells
por: Elrefaei, Mohamed, et al.
Publicado: (2009)

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8(+) T Cells Independently of CD4(+)T Cell Help
por: McCoy, Kathy D., et al.
Publicado: (1999)

Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells
por: Rashidian, Mohammad, et al.
Publicado: (2017)

Regulation of CD4(+)CD8(−)CD25(+) and CD4(+)CD8(+)CD25(+) T cells by gut microbiota in chicken
por: Lee, In Kyu, et al.
Publicado: (2018)

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
por: Lin, Hua, et al.
Publicado: (1998)

CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
por: Friedline, Randall H., et al.
Publicado: (2009)

CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
por: Friedline, Randall H., et al.
Publicado: (2009)

CD117(+)CD44(+) Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway
por: Wei, Yang, et al.
Publicado: (2017)

Visualization of CD4/CD8 T Cell Commitment
por: Chan, Susan, et al.
Publicado: (1998)

Modulation of Regulatory T Cells Activity by Distinct CD80 and CD86 Interactions With CD28/CTLA-4 in Chagas Cardiomyopathy
por: Pinto, Bruna F., et al.
Publicado: (2022)

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation
por: Kennedy, Alan, et al.
Publicado: (2022)

Hydroxychloroquine inhibits CD154 expression in CD4(+) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling
por: Wu, Shu-Fen, et al.
Publicado: (2017)

CTLA-4 antibody ipilimumab negatively affects CD4(+) T-cell responses in vitro
por: Rosskopf, Sandra, et al.
Publicado: (2019)

Porcine NK Cells Stimulate Proliferation of Pseudorabies Virus-Experienced CD8(+) and CD4(+)CD8(+) T Cells
por: De Pelsmaeker, Steffi, et al.
Publicado: (2019)

Long terms trends in CD4(+) cell counts, CD8(+) cell counts, and the CD4(+) : CD8(+) ratio
por: Hughes, Rachael A., et al.
Publicado: (2018)

NFAT2 Regulates Generation of Innate-Like CD8(+) T Lymphocytes and CD8(+) T Lymphocytes Responses
por: Pachulec, Emilia, et al.
Publicado: (2016)

Distinct and Overlapping Effector Functions of Expanded Human CD4(+), CD8α(+) and CD4(-)CD8α(-) Invariant Natural Killer T Cells
por: O'Reilly, Vincent, et al.
Publicado: (2011)

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
Publicado: (1992)

Combining CD4 recovery and CD4: CD8 ratio restoration as an indicator for evaluating the outcome of continued antiretroviral therapy: an observational cohort study
por: Lee, Shui Shan, et al.
Publicado: (2017)

Monitoring CD8a(+) T Cell Responses to Radiotherapy and CTLA-4 Blockade Using [(64)Cu]NOTA-CD8a PET Imaging
por: Kristensen, Lotte K., et al.
Publicado: (2020)

Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity
por: Nawaf, Maher G., et al.
Publicado: (2017)

ICOS Regulates the Generation and Function of Human CD4(+) Treg in a CTLA-4 Dependent Manner
por: Zheng, Jian, et al.
Publicado: (2013)

Role of CD4(+)T, CD8(+)T Cells, and CD4(+)T/CD8(+)T Cell Ratio in Gastric Cancer and Its Clinical Significance
por: Han, Jingqi, et al.
Publicado: (2022)

CD4(+) and CD8(+) T Cell Activation Are Associated with HIV DNA in Resting CD4(+) T Cells
por: Cockerham, Leslie R., et al.
Publicado: (2014)

NFAT primes the human RORC locus for RORγt expression in CD4(+) T cells
por: Yahia-Cherbal, Hanane, et al.
Publicado: (2019)

CD39(+) conventional CD4(+) T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade
por: Bossio, Sabrina N., et al.
Publicado: (2023)

CD8 is required during positive selection of CD4-/CD8+ T cells
Publicado: (1990)

CD32 is enriched on CD4(dim)CD8(bright) T cells
por: Virdi, Amber K., et al.
Publicado: (2020)

CD4+ but not CD8+ cells are essential for allorejection
Publicado: (1996)

Conversion of the CD8 lineage to CD4 T cells
por: Guzman, Maria P., et al.
Publicado: (2015)

Retracted: Role of CD4(+)T, CD8(+)T Cells, and CD4(+)T/CD8(+)T Cell Ratio in Gastric Cancer and Its Clinical Significance
por: and Biomechanics, Applied Bionics
Publicado: (2023)

Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events
por: Martínez-Sanz, Javier, et al.
Publicado: (2023)

Blood PD-1(+)TFh and CTLA-4(+)CD4(+) T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis
por: Aldridge, Jonathan, et al.
Publicado: (2021)

CD8 and CD4 T Cell Populations in Human Kidneys
por: van der Putten, Carlos, et al.
Publicado: (2021)

In Vivo Dynamical Interactions between CD4 Tregs, CD8 Tregs and CD4(+)CD25(−) Cells in Mice
por: Arazi, Arnon, et al.
Publicado: (2009)

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
Publicado: (1995)

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
por: Nakamoto, Nobuhiro, et al.
Publicado: (2009)

Transcriptional signatures of Itk-deficient CD3(+), CD4(+ )and CD8(+ )T-cells
por: Blomberg, K Emelie M, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_svpq6kg96ml38n1ir9ggeumm5o