Pituitary adenylate cyclase activating polypeptide and migraine

Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with mo...

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Detalles Bibliográficos
Autores principales: Zagami, Alessandro S, Edvinsson, Lars, Goadsby, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284128/
https://www.ncbi.nlm.nih.gov/pubmed/25574477
http://dx.doi.org/10.1002/acn3.113
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author Zagami, Alessandro S
Edvinsson, Lars
Goadsby, Peter J
author_facet Zagami, Alessandro S
Edvinsson, Lars
Goadsby, Peter J
author_sort Zagami, Alessandro S
collection PubMed
description Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics.
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spelling pubmed-42841282015-01-08 Pituitary adenylate cyclase activating polypeptide and migraine Zagami, Alessandro S Edvinsson, Lars Goadsby, Peter J Ann Clin Transl Neurol Brief Communications Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics. Blackwell Publishing Ltd 2014-12 2014-11-12 /pmc/articles/PMC4284128/ /pubmed/25574477 http://dx.doi.org/10.1002/acn3.113 Text en © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Zagami, Alessandro S
Edvinsson, Lars
Goadsby, Peter J
Pituitary adenylate cyclase activating polypeptide and migraine
title Pituitary adenylate cyclase activating polypeptide and migraine
title_full Pituitary adenylate cyclase activating polypeptide and migraine
title_fullStr Pituitary adenylate cyclase activating polypeptide and migraine
title_full_unstemmed Pituitary adenylate cyclase activating polypeptide and migraine
title_short Pituitary adenylate cyclase activating polypeptide and migraine
title_sort pituitary adenylate cyclase activating polypeptide and migraine
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284128/
https://www.ncbi.nlm.nih.gov/pubmed/25574477
http://dx.doi.org/10.1002/acn3.113
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