Multiple Nonglycemic Genomic Loci Are Newly Associated With Blood Level of Glycated Hemoglobin in East Asians

Glycated hemoglobin A(1c) (HbA(1c)) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA(1c) in East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026)...

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Detalles Bibliográficos
Autores principales: Chen, Peng, Takeuchi, Fumihiko, Lee, Jong-Young, Li, Huaixing, Wu, Jer-Yuarn, Liang, Jun, Long, Jirong, Tabara, Yasuharu, Goodarzi, Mark O., Pereira, Mark A., Kim, Young Jin, Go, Min Jin, Stram, Daniel O., Vithana, Eranga, Khor, Chiea-Chuen, Liu, Jianjun, Liao, Jiemin, Ye, Xingwang, Wang, Yiqin, Lu, Ling, Young, Terri L., Lee, Jeannette, Thai, Ah Chuan, Cheng, Ching-Yu, van Dam, Rob M., Friedlander, Yechiel, Heng, Chew-Kiat, Koh, Woon-Puay, Chen, Chien-Hsiun, Chang, Li-Ching, Pan, Wen-Harn, Qi, Qibin, Isono, Masato, Zheng, Wei, Cai, Qiuyin, Gao, Yutang, Yamamoto, Ken, Ohnaka, Keizo, Takayanagi, Ryoichi, Kita, Yoshikuni, Ueshima, Hirotsugu, Hsiung, Chao A., Cui, Jinrui, Sheu, Wayne H.-H., Rotter, Jerome I., Chen, Yii-Der I., Hsu, Chris, Okada, Yukinori, Kubo, Michiaki, Takahashi, Atsushi, Tanaka, Toshihiro, van Rooij, Frank J.A., Ganesh, Santhi K., Huang, Jinyan, Huang, Tao, Yuan, Jianmin, Hwang, Joo-Yeon, Gross, Myron D., Assimes, Themistocles L., Miki, Tetsuro, Shu, Xiao-Ou, Qi, Lu, Chen, Yuan-Tson, Lin, Xu, Aung, Tin, Wong, Tien-Yin, Teo, Yik-Ying, Kim, Bong-Jo, Kato, Norihiro, Tai, E-Shyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284402/
https://www.ncbi.nlm.nih.gov/pubmed/24647736
http://dx.doi.org/10.2337/db13-1815

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