Resistance to c-Kit inhibitors in melanoma: insights for future therapies

Mutations activating the receptor tyrosine kinase c-Kit occur commonly in melanomas arising on mucosal membranes and acral skin. Clinical studies have demonstrated that selective inhibition of c-Kit is effective in treating patients with c-Kit mutant gastrointestinal stromal tumors, but c-Kit inhibi...

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Detalles Bibliográficos
Autores principales: Carlino, Matteo S., Todd, Jason R., Rizos, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284619/
https://www.ncbi.nlm.nih.gov/pubmed/25594040

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