Cargando…

Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions

Cell death overarches carcinogenesis and is a center of cancer researches, especially therapy studies. There have been many nomenclatures on cell death, but only three cell death modes are genuine, i.e. apoptosis, necrosis and stress-induced cell death (SICD). Like apoptosis, SICD is programmed. Lik...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Ju, Lou, Xiaomin, Jin, Longyu, Zhou, Rongjia, Liu, Siqi, Xu, Ningzhi, Liao, D. Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284620/
https://www.ncbi.nlm.nih.gov/pubmed/25594039
_version_ 1782351411817742336
author Zhang, Ju
Lou, Xiaomin
Jin, Longyu
Zhou, Rongjia
Liu, Siqi
Xu, Ningzhi
Liao, D. Joshua
author_facet Zhang, Ju
Lou, Xiaomin
Jin, Longyu
Zhou, Rongjia
Liu, Siqi
Xu, Ningzhi
Liao, D. Joshua
author_sort Zhang, Ju
collection PubMed
description Cell death overarches carcinogenesis and is a center of cancer researches, especially therapy studies. There have been many nomenclatures on cell death, but only three cell death modes are genuine, i.e. apoptosis, necrosis and stress-induced cell death (SICD). Like apoptosis, SICD is programmed. Like necrosis, SICD is a pathological event and may trigger regeneration and scar formation. Therefore, SICD has subtypes of stress-induced apoptosis-like cell death (SIaLCD) and stress-induced necrosis-like cell death (SInLCD). Whereas apoptosis removes redundant but healthy cells, SICD removes useful but ill or damaged cells. Many studies on cell death involve cancer tissues that resemble parasites in the host patients, which is a complicated system as it involves immune clearance of the alien cancer cells by the host. Cancer resembles an evolutionarily lower-level organism having a weaker apoptosis potential and poorer DNA repair mechanisms. Hence, targeting apoptosis for cancer therapy, i.e. killing via SIaLCD, will be less efficacious and more toxic. On the other hand, necrosis of cancer cells releases cellular debris and components to stimulate immune function, thus counteracting therapy-caused immune suppression and making necrosis better than SIaLCD for chemo drug development.
format Online
Article
Text
id pubmed-4284620
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-42846202015-01-15 Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions Zhang, Ju Lou, Xiaomin Jin, Longyu Zhou, Rongjia Liu, Siqi Xu, Ningzhi Liao, D. Joshua Oncoscience Review Cell death overarches carcinogenesis and is a center of cancer researches, especially therapy studies. There have been many nomenclatures on cell death, but only three cell death modes are genuine, i.e. apoptosis, necrosis and stress-induced cell death (SICD). Like apoptosis, SICD is programmed. Like necrosis, SICD is a pathological event and may trigger regeneration and scar formation. Therefore, SICD has subtypes of stress-induced apoptosis-like cell death (SIaLCD) and stress-induced necrosis-like cell death (SInLCD). Whereas apoptosis removes redundant but healthy cells, SICD removes useful but ill or damaged cells. Many studies on cell death involve cancer tissues that resemble parasites in the host patients, which is a complicated system as it involves immune clearance of the alien cancer cells by the host. Cancer resembles an evolutionarily lower-level organism having a weaker apoptosis potential and poorer DNA repair mechanisms. Hence, targeting apoptosis for cancer therapy, i.e. killing via SIaLCD, will be less efficacious and more toxic. On the other hand, necrosis of cancer cells releases cellular debris and components to stimulate immune function, thus counteracting therapy-caused immune suppression and making necrosis better than SIaLCD for chemo drug development. Impact Journals LLC 2014-07-03 /pmc/articles/PMC4284620/ /pubmed/25594039 Text en © 2014 Zhang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Zhang, Ju
Lou, Xiaomin
Jin, Longyu
Zhou, Rongjia
Liu, Siqi
Xu, Ningzhi
Liao, D. Joshua
Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions
title Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions
title_full Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions
title_fullStr Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions
title_full_unstemmed Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions
title_short Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions
title_sort necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284620/
https://www.ncbi.nlm.nih.gov/pubmed/25594039
work_keys_str_mv AT zhangju necrosisandthenstressinducednecrosislikecelldeathbutnotapoptosisshouldbethepreferredcelldeathmodeforchemotherapyclearanceofafewmisconceptions
AT louxiaomin necrosisandthenstressinducednecrosislikecelldeathbutnotapoptosisshouldbethepreferredcelldeathmodeforchemotherapyclearanceofafewmisconceptions
AT jinlongyu necrosisandthenstressinducednecrosislikecelldeathbutnotapoptosisshouldbethepreferredcelldeathmodeforchemotherapyclearanceofafewmisconceptions
AT zhourongjia necrosisandthenstressinducednecrosislikecelldeathbutnotapoptosisshouldbethepreferredcelldeathmodeforchemotherapyclearanceofafewmisconceptions
AT liusiqi necrosisandthenstressinducednecrosislikecelldeathbutnotapoptosisshouldbethepreferredcelldeathmodeforchemotherapyclearanceofafewmisconceptions
AT xuningzhi necrosisandthenstressinducednecrosislikecelldeathbutnotapoptosisshouldbethepreferredcelldeathmodeforchemotherapyclearanceofafewmisconceptions
AT liaodjoshua necrosisandthenstressinducednecrosislikecelldeathbutnotapoptosisshouldbethepreferredcelldeathmodeforchemotherapyclearanceofafewmisconceptions