Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation

Kit is a receptor-type tyrosine kinase found on the plasma membrane. It can transform mast cells through activating mutations. Here, we show that a mutant Kit from neoplastic mast cells from mice, Kit(D814Y), is permanently active and allows cells to proliferate autonomously. It does so by activatin...

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Detalles Bibliográficos
Autores principales: Obata, Yuuki, Toyoshima, Shota, Wakamatsu, Ei, Suzuki, Shunichi, Ogawa, Shuhei, Esumi, Hiroyasu, Abe, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284665/
https://www.ncbi.nlm.nih.gov/pubmed/25493654
http://dx.doi.org/10.1038/ncomms6715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284665/
https://www.ncbi.nlm.nih.gov/pubmed/25493654
http://dx.doi.org/10.1038/ncomms6715

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