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Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival

Epithelial-to-mesenchymal transition (EMT) facilitates tumor metastasis. Twist is a basic helix-loop-helix protein that modulates many target genes through E-box-responsive elements. There are two twist-like proteins, Twist-1 and Twist-2, sharing high structural homology in mammals. Twist-1 was foun...

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Autores principales: Wushou, Alimujiang, Hou, Jing, Zhao, Ya-Jun, Shao, Zhi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284667/
https://www.ncbi.nlm.nih.gov/pubmed/25429425
http://dx.doi.org/10.3390/ijms151221621
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author Wushou, Alimujiang
Hou, Jing
Zhao, Ya-Jun
Shao, Zhi-Ming
author_facet Wushou, Alimujiang
Hou, Jing
Zhao, Ya-Jun
Shao, Zhi-Ming
author_sort Wushou, Alimujiang
collection PubMed
description Epithelial-to-mesenchymal transition (EMT) facilitates tumor metastasis. Twist is a basic helix-loop-helix protein that modulates many target genes through E-box-responsive elements. There are two twist-like proteins, Twist-1 and Twist-2, sharing high structural homology in mammals. Twist-1 was found to be a key factor in the promotion of metastasis of cancer cells, and is known to induce EMT. Twist-1 participation in carcinoma progression and metastasis has been reported in a variety of tumors. However, controversy exists concerning the correlation between Twist-1 and prognostic value with respect to carcinoma. A systematic review and meta-analysis were performed to determine whether the expression of Twist-1 was associated with the prognosis of carcinoma patients. This analysis included 17 studies: four studies evaluated lung cancer, three evaluated head and neck cancer, two evaluated breast cancer, two evaluated esophageal cancer, two evaluated liver cancer and one each evaluated osteosarcoma, bladder, cervical and ovarian cancer. A total of 2006 patients were enrolled in these studies, and the median trial sample size was 118 patients. Twist-1 expression was associated with worse overall survival (OS) at both 3 years (hazard ratio “HR” for death = 2.13, 95% CI = 1.86 to 2.45, p < 0.001) and 5 years (HR for death = 2.01, 95% CI = 1.76 to 2.29, p < 0.001). Expression of Twist-1 is associated with worse survival in carcinoma.
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spelling pubmed-42846672015-01-21 Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival Wushou, Alimujiang Hou, Jing Zhao, Ya-Jun Shao, Zhi-Ming Int J Mol Sci Article Epithelial-to-mesenchymal transition (EMT) facilitates tumor metastasis. Twist is a basic helix-loop-helix protein that modulates many target genes through E-box-responsive elements. There are two twist-like proteins, Twist-1 and Twist-2, sharing high structural homology in mammals. Twist-1 was found to be a key factor in the promotion of metastasis of cancer cells, and is known to induce EMT. Twist-1 participation in carcinoma progression and metastasis has been reported in a variety of tumors. However, controversy exists concerning the correlation between Twist-1 and prognostic value with respect to carcinoma. A systematic review and meta-analysis were performed to determine whether the expression of Twist-1 was associated with the prognosis of carcinoma patients. This analysis included 17 studies: four studies evaluated lung cancer, three evaluated head and neck cancer, two evaluated breast cancer, two evaluated esophageal cancer, two evaluated liver cancer and one each evaluated osteosarcoma, bladder, cervical and ovarian cancer. A total of 2006 patients were enrolled in these studies, and the median trial sample size was 118 patients. Twist-1 expression was associated with worse overall survival (OS) at both 3 years (hazard ratio “HR” for death = 2.13, 95% CI = 1.86 to 2.45, p < 0.001) and 5 years (HR for death = 2.01, 95% CI = 1.76 to 2.29, p < 0.001). Expression of Twist-1 is associated with worse survival in carcinoma. MDPI 2014-11-25 /pmc/articles/PMC4284667/ /pubmed/25429425 http://dx.doi.org/10.3390/ijms151221621 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wushou, Alimujiang
Hou, Jing
Zhao, Ya-Jun
Shao, Zhi-Ming
Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival
title Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival
title_full Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival
title_fullStr Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival
title_full_unstemmed Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival
title_short Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival
title_sort twist-1 up-regulation in carcinoma correlates to poor survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284667/
https://www.ncbi.nlm.nih.gov/pubmed/25429425
http://dx.doi.org/10.3390/ijms151221621
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