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Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China

Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms are common genetic determinants of homocysteine levels. To investigate the associatio...

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Autores principales: Yang, Boyi, Fan, Shujun, Zhi, Xueyuan, Wang, Da, Li, Yongfang, Wang, Yinuo, Wang, Yanxun, Wei, Jian, Zheng, Quanmei, Sun, Guifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284672/
https://www.ncbi.nlm.nih.gov/pubmed/25429430
http://dx.doi.org/10.3390/ijms151221687
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author Yang, Boyi
Fan, Shujun
Zhi, Xueyuan
Wang, Da
Li, Yongfang
Wang, Yinuo
Wang, Yanxun
Wei, Jian
Zheng, Quanmei
Sun, Guifan
author_facet Yang, Boyi
Fan, Shujun
Zhi, Xueyuan
Wang, Da
Li, Yongfang
Wang, Yinuo
Wang, Yanxun
Wei, Jian
Zheng, Quanmei
Sun, Guifan
author_sort Yang, Boyi
collection PubMed
description Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms are common genetic determinants of homocysteine levels. To investigate the associations of the MTHFR C677T and MTRR A66G polymorphisms with MetS, 692 Chinese Han subjects with MetS and 878 controls were recruited. The component traits of MetS and the MTHFR C677T and MTRR A66G genotypes were determined. A significant association was observed between the MTHFR 677T allele and increased risk of MetS, high fasting blood glucose, high waist circumference, and increasing number of MetS components. The MTRR A66G polymorphism was associated with an increased risk of MetS when combined with the MTHFR 677TT genotype, although there was no association found between MetS and MTRR A66G alone. Furthermore, the MTRR 66GG genotype was associated with high fasting blood glucose and triglycerides. Our data suggest that the MTHFR 677T allele may contribute to an increased risk of MetS in the northern Chinese Han population. The MTRR A66G polymorphism is not associated with MetS. However, it may exacerbate the effect of the MTHFR C677T variant alone. Further large prospective population-based studies are required to confirm our findings.
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spelling pubmed-42846722015-01-21 Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China Yang, Boyi Fan, Shujun Zhi, Xueyuan Wang, Da Li, Yongfang Wang, Yinuo Wang, Yanxun Wei, Jian Zheng, Quanmei Sun, Guifan Int J Mol Sci Article Prior evidence indicates that homocysteine plays a role in the development of metabolic syndrome (MetS). Methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms are common genetic determinants of homocysteine levels. To investigate the associations of the MTHFR C677T and MTRR A66G polymorphisms with MetS, 692 Chinese Han subjects with MetS and 878 controls were recruited. The component traits of MetS and the MTHFR C677T and MTRR A66G genotypes were determined. A significant association was observed between the MTHFR 677T allele and increased risk of MetS, high fasting blood glucose, high waist circumference, and increasing number of MetS components. The MTRR A66G polymorphism was associated with an increased risk of MetS when combined with the MTHFR 677TT genotype, although there was no association found between MetS and MTRR A66G alone. Furthermore, the MTRR 66GG genotype was associated with high fasting blood glucose and triglycerides. Our data suggest that the MTHFR 677T allele may contribute to an increased risk of MetS in the northern Chinese Han population. The MTRR A66G polymorphism is not associated with MetS. However, it may exacerbate the effect of the MTHFR C677T variant alone. Further large prospective population-based studies are required to confirm our findings. MDPI 2014-11-25 /pmc/articles/PMC4284672/ /pubmed/25429430 http://dx.doi.org/10.3390/ijms151221687 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Boyi
Fan, Shujun
Zhi, Xueyuan
Wang, Da
Li, Yongfang
Wang, Yinuo
Wang, Yanxun
Wei, Jian
Zheng, Quanmei
Sun, Guifan
Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China
title Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China
title_full Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China
title_fullStr Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China
title_full_unstemmed Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China
title_short Associations of MTHFR C677T and MTRR A66G Gene Polymorphisms with Metabolic Syndrome: A Case-Control Study in Northern China
title_sort associations of mthfr c677t and mtrr a66g gene polymorphisms with metabolic syndrome: a case-control study in northern china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284672/
https://www.ncbi.nlm.nih.gov/pubmed/25429430
http://dx.doi.org/10.3390/ijms151221687
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