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ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases

Mammalian cytokinesis proceeds by constriction of an actomyosin ring and furrow ingression, resulting in the formation of the midbody bridge connecting two daughter cells. At the centre of the midbody resides the Flemming body, a dense proteinaceous ring surrounding the interlocking ends of anti-par...

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Autores principales: Bhutta, Musab S., McInerny, Christopher J., Gould, Gwyn W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284674/
https://www.ncbi.nlm.nih.gov/pubmed/25429432
http://dx.doi.org/10.3390/ijms151221723
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author Bhutta, Musab S.
McInerny, Christopher J.
Gould, Gwyn W.
author_facet Bhutta, Musab S.
McInerny, Christopher J.
Gould, Gwyn W.
author_sort Bhutta, Musab S.
collection PubMed
description Mammalian cytokinesis proceeds by constriction of an actomyosin ring and furrow ingression, resulting in the formation of the midbody bridge connecting two daughter cells. At the centre of the midbody resides the Flemming body, a dense proteinaceous ring surrounding the interlocking ends of anti-parallel microtubule arrays. Abscission, the terminal step of cytokinesis, occurs near the Flemming body. A series of broad processes govern abscission: the initiation and stabilisation of the abscission zone, followed by microtubule severing and membrane scission—The latter mediated by the endosomal sorting complex required for transport (ESCRT) proteins. A key goal of cell and developmental biologists is to develop a clear understanding of the mechanisms that underpin abscission, and how the spatiotemporal coordination of these events with previous stages in cell division is accomplished. This article will focus on the function and dynamics of the ESCRT proteins in abscission and will review recent work, which has begun to explore how these complex protein assemblies are regulated by the cell cycle machinery.
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spelling pubmed-42846742015-01-21 ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases Bhutta, Musab S. McInerny, Christopher J. Gould, Gwyn W. Int J Mol Sci Review Mammalian cytokinesis proceeds by constriction of an actomyosin ring and furrow ingression, resulting in the formation of the midbody bridge connecting two daughter cells. At the centre of the midbody resides the Flemming body, a dense proteinaceous ring surrounding the interlocking ends of anti-parallel microtubule arrays. Abscission, the terminal step of cytokinesis, occurs near the Flemming body. A series of broad processes govern abscission: the initiation and stabilisation of the abscission zone, followed by microtubule severing and membrane scission—The latter mediated by the endosomal sorting complex required for transport (ESCRT) proteins. A key goal of cell and developmental biologists is to develop a clear understanding of the mechanisms that underpin abscission, and how the spatiotemporal coordination of these events with previous stages in cell division is accomplished. This article will focus on the function and dynamics of the ESCRT proteins in abscission and will review recent work, which has begun to explore how these complex protein assemblies are regulated by the cell cycle machinery. MDPI 2014-11-25 /pmc/articles/PMC4284674/ /pubmed/25429432 http://dx.doi.org/10.3390/ijms151221723 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bhutta, Musab S.
McInerny, Christopher J.
Gould, Gwyn W.
ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
title ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
title_full ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
title_fullStr ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
title_full_unstemmed ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
title_short ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
title_sort escrt function in cytokinesis: location, dynamics and regulation by mitotic kinases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284674/
https://www.ncbi.nlm.nih.gov/pubmed/25429432
http://dx.doi.org/10.3390/ijms151221723
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