Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory acti...

Descripción completa

Detalles Bibliográficos
Autores principales: Tai, Chi-Jen, Chokkalingam, Uvarani, Cheng, Yang, Shih, Shou-Ping, Lu, Mei-Chin, Su, Jui-Hsin, Hwang, Tsong-Long, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284682/
https://www.ncbi.nlm.nih.gov/pubmed/25437917
http://dx.doi.org/10.3390/ijms151221865
_version_ 1782351428367417344
author Tai, Chi-Jen
Chokkalingam, Uvarani
Cheng, Yang
Shih, Shou-Ping
Lu, Mei-Chin
Su, Jui-Hsin
Hwang, Tsong-Long
Sheu, Jyh-Horng
author_facet Tai, Chi-Jen
Chokkalingam, Uvarani
Cheng, Yang
Shih, Shou-Ping
Lu, Mei-Chin
Su, Jui-Hsin
Hwang, Tsong-Long
Sheu, Jyh-Horng
author_sort Tai, Chi-Jen
collection PubMed
description Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.
format Online
Article
Text
id pubmed-4284682
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-42846822015-01-21 Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi Tai, Chi-Jen Chokkalingam, Uvarani Cheng, Yang Shih, Shou-Ping Lu, Mei-Chin Su, Jui-Hsin Hwang, Tsong-Long Sheu, Jyh-Horng Int J Mol Sci Article Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported. MDPI 2014-11-27 /pmc/articles/PMC4284682/ /pubmed/25437917 http://dx.doi.org/10.3390/ijms151221865 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tai, Chi-Jen
Chokkalingam, Uvarani
Cheng, Yang
Shih, Shou-Ping
Lu, Mei-Chin
Su, Jui-Hsin
Hwang, Tsong-Long
Sheu, Jyh-Horng
Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_full Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_fullStr Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_full_unstemmed Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_short Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
title_sort krempfielins q and r, two new eunicellin-based diterpenoids from the soft coral cladiella krempfi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284682/
https://www.ncbi.nlm.nih.gov/pubmed/25437917
http://dx.doi.org/10.3390/ijms151221865
work_keys_str_mv AT taichijen krempfielinsqandrtwoneweunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi
AT chokkalingamuvarani krempfielinsqandrtwoneweunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi
AT chengyang krempfielinsqandrtwoneweunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi
AT shihshouping krempfielinsqandrtwoneweunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi
AT lumeichin krempfielinsqandrtwoneweunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi
AT sujuihsin krempfielinsqandrtwoneweunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi
AT hwangtsonglong krempfielinsqandrtwoneweunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi
AT sheujyhhorng krempfielinsqandrtwoneweunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi

Ejemplares similares