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A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery Disease

Insulin resistance and obesity is influenced by the retinol binding protein 4 (RBP4) adipokine. This study aims to determine if genetic polymorphisms in RBP4 are associated with the risk of coronary artery disease (CAD) in Chinese patients. RBP4 polymorphisms were analyzed by high resolution melting...

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Autores principales: Wan, Ke, Zhao, Jianxun, Deng, Ying, Chen, Xi, Zhang, Qing, Zeng, Zhi, Zhang, Li, Chen, Yucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284709/
https://www.ncbi.nlm.nih.gov/pubmed/25479076
http://dx.doi.org/10.3390/ijms151222309
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author Wan, Ke
Zhao, Jianxun
Deng, Ying
Chen, Xi
Zhang, Qing
Zeng, Zhi
Zhang, Li
Chen, Yucheng
author_facet Wan, Ke
Zhao, Jianxun
Deng, Ying
Chen, Xi
Zhang, Qing
Zeng, Zhi
Zhang, Li
Chen, Yucheng
author_sort Wan, Ke
collection PubMed
description Insulin resistance and obesity is influenced by the retinol binding protein 4 (RBP4) adipokine. This study aims to determine if genetic polymorphisms in RBP4 are associated with the risk of coronary artery disease (CAD) in Chinese patients. RBP4 polymorphisms were analyzed by high resolution melting (HRM) analysis in a case-control study of 392 unrelated CAD patients and 368 controls from China. The Gensini score was used to determine the severity of CAD. The genotypic and allelic frequencies of RBP4 single-nucleotide polymorphisms were evaluated for associations with CAD and severity of disease. The A allele frequency was significantly higher in CAD case groups compared to control groups (16.7% vs. 8.8%) at the RBP4 rs7094671 locus. Compared to the G allele, this allele was associated with a higher risk of CAD (OR = 2.07 (1.50–2.84)). Polymorphisms at rs7094671 were found to associate with CAD using either a dominant or recessive model (OR, 95% CI: 1.97, 1.38–2.81; 3.81, 1.53–9.51, respectively). Adjusting for sex, history of smoking, serum TC, TG, LDL-c, and HDL-c, the risk of CAD for carriers remained significantly higher in both dominant and recessive models (OR, 95% CI: 1.68, 1.12–2.51; 2.74, 1.00–7.52, respectively). However, this SNP was not significantly associated with severity of CAD using angiographic scores in multivariable linear regression models (p = 0.373). The RBP4 rs7094671 SNP is associated with CAD; however, our results do not indicate that this locus is associated with clinical severity of CAD or the extent of coronary lesions.
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spelling pubmed-42847092015-01-21 A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery Disease Wan, Ke Zhao, Jianxun Deng, Ying Chen, Xi Zhang, Qing Zeng, Zhi Zhang, Li Chen, Yucheng Int J Mol Sci Article Insulin resistance and obesity is influenced by the retinol binding protein 4 (RBP4) adipokine. This study aims to determine if genetic polymorphisms in RBP4 are associated with the risk of coronary artery disease (CAD) in Chinese patients. RBP4 polymorphisms were analyzed by high resolution melting (HRM) analysis in a case-control study of 392 unrelated CAD patients and 368 controls from China. The Gensini score was used to determine the severity of CAD. The genotypic and allelic frequencies of RBP4 single-nucleotide polymorphisms were evaluated for associations with CAD and severity of disease. The A allele frequency was significantly higher in CAD case groups compared to control groups (16.7% vs. 8.8%) at the RBP4 rs7094671 locus. Compared to the G allele, this allele was associated with a higher risk of CAD (OR = 2.07 (1.50–2.84)). Polymorphisms at rs7094671 were found to associate with CAD using either a dominant or recessive model (OR, 95% CI: 1.97, 1.38–2.81; 3.81, 1.53–9.51, respectively). Adjusting for sex, history of smoking, serum TC, TG, LDL-c, and HDL-c, the risk of CAD for carriers remained significantly higher in both dominant and recessive models (OR, 95% CI: 1.68, 1.12–2.51; 2.74, 1.00–7.52, respectively). However, this SNP was not significantly associated with severity of CAD using angiographic scores in multivariable linear regression models (p = 0.373). The RBP4 rs7094671 SNP is associated with CAD; however, our results do not indicate that this locus is associated with clinical severity of CAD or the extent of coronary lesions. MDPI 2014-12-03 /pmc/articles/PMC4284709/ /pubmed/25479076 http://dx.doi.org/10.3390/ijms151222309 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wan, Ke
Zhao, Jianxun
Deng, Ying
Chen, Xi
Zhang, Qing
Zeng, Zhi
Zhang, Li
Chen, Yucheng
A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery Disease
title A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery Disease
title_full A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery Disease
title_fullStr A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery Disease
title_full_unstemmed A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery Disease
title_short A Genetic Polymorphism in RBP4 Is Associated with Coronary Artery Disease
title_sort genetic polymorphism in rbp4 is associated with coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284709/
https://www.ncbi.nlm.nih.gov/pubmed/25479076
http://dx.doi.org/10.3390/ijms151222309
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