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Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease
YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and l...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284717/ https://www.ncbi.nlm.nih.gov/pubmed/25486056 http://dx.doi.org/10.3390/ijms151222421 |
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author | Wu, Semon Hsu, Lung-An Cheng, Shih-Tsung Teng, Ming-Sheng Yeh, Ching-Hua Sun, Yu-Chen Huang, Hsuan-Li Ko, Yu-Lin |
author_facet | Wu, Semon Hsu, Lung-An Cheng, Shih-Tsung Teng, Ming-Sheng Yeh, Ching-Hua Sun, Yu-Chen Huang, Hsuan-Li Ko, Yu-Lin |
author_sort | Wu, Semon |
collection | PubMed |
description | YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and long-term mortality of peripheral artery disease (PAD). Plasma YKL-40 concentrations were measured in 612 Taiwanese individuals who had no clinically overt systemic disease. Clinical parameters, CHI3L1 gene promoter variants and 18 biomarker levels were analyzed. Eighty-six PAD patients were further enrolled for analysis. Significant associations were found between CHI3L1 genotypes/haplotypes and YKL-40 levels for the health examination subjects (smallest p = 8.36 × 10(−7) for rs4950928 and smallest p = 1.72 × 10(−10) for haplotype TGG) and also for PAD patients. For the health examination subjects, circulating YKL-40 level, but not CHI3L1 gene variants, were positively associated with age, smoking, and circulating levels of triglyceride, lipocalin 2 and multiple inflammatory biomarkers and negatively associated with low-density-lipoprotein cholesterol levels. Circulating YKL-40 level is also significantly associated with the risk of PAD (p = 3.3 × 10(−23)). Circulating YKL40 level, but not CHI3L1 gene promoter variants, is associated with the risk of PAD in Taiwanese. The association of YKL-40 levels with multiple quantitative traits relating to the risk of PAD may provide a molecular basis linking YKL-40 to atherosclerotic cardiovascular disease. |
format | Online Article Text |
id | pubmed-4284717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42847172015-01-21 Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease Wu, Semon Hsu, Lung-An Cheng, Shih-Tsung Teng, Ming-Sheng Yeh, Ching-Hua Sun, Yu-Chen Huang, Hsuan-Li Ko, Yu-Lin Int J Mol Sci Article YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and long-term mortality of peripheral artery disease (PAD). Plasma YKL-40 concentrations were measured in 612 Taiwanese individuals who had no clinically overt systemic disease. Clinical parameters, CHI3L1 gene promoter variants and 18 biomarker levels were analyzed. Eighty-six PAD patients were further enrolled for analysis. Significant associations were found between CHI3L1 genotypes/haplotypes and YKL-40 levels for the health examination subjects (smallest p = 8.36 × 10(−7) for rs4950928 and smallest p = 1.72 × 10(−10) for haplotype TGG) and also for PAD patients. For the health examination subjects, circulating YKL-40 level, but not CHI3L1 gene variants, were positively associated with age, smoking, and circulating levels of triglyceride, lipocalin 2 and multiple inflammatory biomarkers and negatively associated with low-density-lipoprotein cholesterol levels. Circulating YKL-40 level is also significantly associated with the risk of PAD (p = 3.3 × 10(−23)). Circulating YKL40 level, but not CHI3L1 gene promoter variants, is associated with the risk of PAD in Taiwanese. The association of YKL-40 levels with multiple quantitative traits relating to the risk of PAD may provide a molecular basis linking YKL-40 to atherosclerotic cardiovascular disease. MDPI 2014-12-04 /pmc/articles/PMC4284717/ /pubmed/25486056 http://dx.doi.org/10.3390/ijms151222421 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wu, Semon Hsu, Lung-An Cheng, Shih-Tsung Teng, Ming-Sheng Yeh, Ching-Hua Sun, Yu-Chen Huang, Hsuan-Li Ko, Yu-Lin Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease |
title | Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease |
title_full | Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease |
title_fullStr | Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease |
title_full_unstemmed | Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease |
title_short | Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease |
title_sort | circulating ykl-40 level, but not chi3l1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284717/ https://www.ncbi.nlm.nih.gov/pubmed/25486056 http://dx.doi.org/10.3390/ijms151222421 |
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