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Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease

YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and l...

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Autores principales: Wu, Semon, Hsu, Lung-An, Cheng, Shih-Tsung, Teng, Ming-Sheng, Yeh, Ching-Hua, Sun, Yu-Chen, Huang, Hsuan-Li, Ko, Yu-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284717/
https://www.ncbi.nlm.nih.gov/pubmed/25486056
http://dx.doi.org/10.3390/ijms151222421
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author Wu, Semon
Hsu, Lung-An
Cheng, Shih-Tsung
Teng, Ming-Sheng
Yeh, Ching-Hua
Sun, Yu-Chen
Huang, Hsuan-Li
Ko, Yu-Lin
author_facet Wu, Semon
Hsu, Lung-An
Cheng, Shih-Tsung
Teng, Ming-Sheng
Yeh, Ching-Hua
Sun, Yu-Chen
Huang, Hsuan-Li
Ko, Yu-Lin
author_sort Wu, Semon
collection PubMed
description YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and long-term mortality of peripheral artery disease (PAD). Plasma YKL-40 concentrations were measured in 612 Taiwanese individuals who had no clinically overt systemic disease. Clinical parameters, CHI3L1 gene promoter variants and 18 biomarker levels were analyzed. Eighty-six PAD patients were further enrolled for analysis. Significant associations were found between CHI3L1 genotypes/haplotypes and YKL-40 levels for the health examination subjects (smallest p = 8.36 × 10(−7) for rs4950928 and smallest p = 1.72 × 10(−10) for haplotype TGG) and also for PAD patients. For the health examination subjects, circulating YKL-40 level, but not CHI3L1 gene variants, were positively associated with age, smoking, and circulating levels of triglyceride, lipocalin 2 and multiple inflammatory biomarkers and negatively associated with low-density-lipoprotein cholesterol levels. Circulating YKL-40 level is also significantly associated with the risk of PAD (p = 3.3 × 10(−23)). Circulating YKL40 level, but not CHI3L1 gene promoter variants, is associated with the risk of PAD in Taiwanese. The association of YKL-40 levels with multiple quantitative traits relating to the risk of PAD may provide a molecular basis linking YKL-40 to atherosclerotic cardiovascular disease.
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spelling pubmed-42847172015-01-21 Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease Wu, Semon Hsu, Lung-An Cheng, Shih-Tsung Teng, Ming-Sheng Yeh, Ching-Hua Sun, Yu-Chen Huang, Hsuan-Li Ko, Yu-Lin Int J Mol Sci Article YKL-40, a pleotropic cytokine, is emerging as a risk factor and a prognostic predictor of atherosclerotic cardiovascular disease. We attempted to elucidate the genetic, clinical and biochemical correlates of circulating YKL-40 level and, by combining it with CHI3L1 gene variants, with the risk and long-term mortality of peripheral artery disease (PAD). Plasma YKL-40 concentrations were measured in 612 Taiwanese individuals who had no clinically overt systemic disease. Clinical parameters, CHI3L1 gene promoter variants and 18 biomarker levels were analyzed. Eighty-six PAD patients were further enrolled for analysis. Significant associations were found between CHI3L1 genotypes/haplotypes and YKL-40 levels for the health examination subjects (smallest p = 8.36 × 10(−7) for rs4950928 and smallest p = 1.72 × 10(−10) for haplotype TGG) and also for PAD patients. For the health examination subjects, circulating YKL-40 level, but not CHI3L1 gene variants, were positively associated with age, smoking, and circulating levels of triglyceride, lipocalin 2 and multiple inflammatory biomarkers and negatively associated with low-density-lipoprotein cholesterol levels. Circulating YKL-40 level is also significantly associated with the risk of PAD (p = 3.3 × 10(−23)). Circulating YKL40 level, but not CHI3L1 gene promoter variants, is associated with the risk of PAD in Taiwanese. The association of YKL-40 levels with multiple quantitative traits relating to the risk of PAD may provide a molecular basis linking YKL-40 to atherosclerotic cardiovascular disease. MDPI 2014-12-04 /pmc/articles/PMC4284717/ /pubmed/25486056 http://dx.doi.org/10.3390/ijms151222421 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Semon
Hsu, Lung-An
Cheng, Shih-Tsung
Teng, Ming-Sheng
Yeh, Ching-Hua
Sun, Yu-Chen
Huang, Hsuan-Li
Ko, Yu-Lin
Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease
title Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease
title_full Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease
title_fullStr Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease
title_full_unstemmed Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease
title_short Circulating YKL-40 Level, but not CHI3L1 Gene Variants, Is Associated with Atherosclerosis-Related Quantitative Traits and the Risk of Peripheral Artery Disease
title_sort circulating ykl-40 level, but not chi3l1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284717/
https://www.ncbi.nlm.nih.gov/pubmed/25486056
http://dx.doi.org/10.3390/ijms151222421
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