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Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population
Recently, a significant epigenetic component in the pathogenesis of Coronary Artery Disease (CAD) has been realized. Here, we evaluated the possible association of candidate Single Nucleotide Polymorphisms (SNPs) in the epigenetic-regulatory gene, DNA methyltransferase 1 (DNMT1), with CAD in Chinese...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284731/ https://www.ncbi.nlm.nih.gov/pubmed/25493477 http://dx.doi.org/10.3390/ijms151222694 |
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author | Peng, Chunyan Deng, Qianyun Li, Zuhua Xiong, Chenling Li, Cong Zheng, Fang |
author_facet | Peng, Chunyan Deng, Qianyun Li, Zuhua Xiong, Chenling Li, Cong Zheng, Fang |
author_sort | Peng, Chunyan |
collection | PubMed |
description | Recently, a significant epigenetic component in the pathogenesis of Coronary Artery Disease (CAD) has been realized. Here, we evaluated the possible association of candidate Single Nucleotide Polymorphisms (SNPs) in the epigenetic-regulatory gene, DNA methyltransferase 1 (DNMT1), with CAD in Chinese Han population. Five tag SNPs (rs16999593, rs2336691, rs2228611, rs4804494, rs7253062) were analyzed by High Resolution Melt (HRM) method in 476 CAD patients and 478 controls. Overall, there were significant differences in the genotype and allele distributions of rs2228611 and rs2336691, between patients and controls. The minor A allele of rs2228611 was associated with a lower risk of CAD (p = 0.034); modest effect in the additive analysis but also marginal significance was found in the recessive model [OR(additive) = 0.404 (0.184, 0.884), p = 0.023 and OR(recessive) = 0.452 (0.213, 0.963), p = 0.040] after adjusting for confounders. While the rs2336691 A allele were associated with a higher risk of developing CAD (p = 0.037); borderline significant association in both additive and dominant models [OR(additive) = 1.632 (1.030, 2.583), p = 0.037 and OR(dominant) = 1.599 (1.020, 2.507), p = 0.040]. In conclusion, these data provide the first evidence that occurrence of CAD may be moderated by genetic variation in the gene involved in the epigenetic machinery. |
format | Online Article Text |
id | pubmed-4284731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42847312015-01-21 Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population Peng, Chunyan Deng, Qianyun Li, Zuhua Xiong, Chenling Li, Cong Zheng, Fang Int J Mol Sci Article Recently, a significant epigenetic component in the pathogenesis of Coronary Artery Disease (CAD) has been realized. Here, we evaluated the possible association of candidate Single Nucleotide Polymorphisms (SNPs) in the epigenetic-regulatory gene, DNA methyltransferase 1 (DNMT1), with CAD in Chinese Han population. Five tag SNPs (rs16999593, rs2336691, rs2228611, rs4804494, rs7253062) were analyzed by High Resolution Melt (HRM) method in 476 CAD patients and 478 controls. Overall, there were significant differences in the genotype and allele distributions of rs2228611 and rs2336691, between patients and controls. The minor A allele of rs2228611 was associated with a lower risk of CAD (p = 0.034); modest effect in the additive analysis but also marginal significance was found in the recessive model [OR(additive) = 0.404 (0.184, 0.884), p = 0.023 and OR(recessive) = 0.452 (0.213, 0.963), p = 0.040] after adjusting for confounders. While the rs2336691 A allele were associated with a higher risk of developing CAD (p = 0.037); borderline significant association in both additive and dominant models [OR(additive) = 1.632 (1.030, 2.583), p = 0.037 and OR(dominant) = 1.599 (1.020, 2.507), p = 0.040]. In conclusion, these data provide the first evidence that occurrence of CAD may be moderated by genetic variation in the gene involved in the epigenetic machinery. MDPI 2014-12-08 /pmc/articles/PMC4284731/ /pubmed/25493477 http://dx.doi.org/10.3390/ijms151222694 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Peng, Chunyan Deng, Qianyun Li, Zuhua Xiong, Chenling Li, Cong Zheng, Fang Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population |
title | Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population |
title_full | Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population |
title_fullStr | Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population |
title_full_unstemmed | Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population |
title_short | Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population |
title_sort | risk-association of dnmt1 gene polymorphisms with coronary artery disease in chinese han population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284731/ https://www.ncbi.nlm.nih.gov/pubmed/25493477 http://dx.doi.org/10.3390/ijms151222694 |
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