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LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284744/ https://www.ncbi.nlm.nih.gov/pubmed/25514242 http://dx.doi.org/10.3390/ijms151222887 |
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author | Lin, Ling Hu, Kebin |
author_facet | Lin, Ling Hu, Kebin |
author_sort | Lin, Ling |
collection | PubMed |
description | Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases. In addition to its function as a scavenger receptor for various ligands, LRP-1 has been shown to transduce multiple intracellular signal pathways including mitogen-activated protein kinase (MAPK), Akt, Rho, and the integrin signaling. LRP-1 signaling plays an important role in the regulation of diverse cellular process, such as cell proliferation, survival, motility, differentiation, and transdifferentiation, and thus participates in the pathogenesis of organ dysfunction and injury. In this review, we focus on the current understanding of LRP-1 signaling and its roles in the development and progression of kidney disease. The role and signaling of LRP-1 in the nervous and cardiovascular systems, as well as in carcinogenesis, are also briefly discussed. |
format | Online Article Text |
id | pubmed-4284744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42847442015-01-21 LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases Lin, Ling Hu, Kebin Int J Mol Sci Review Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases. In addition to its function as a scavenger receptor for various ligands, LRP-1 has been shown to transduce multiple intracellular signal pathways including mitogen-activated protein kinase (MAPK), Akt, Rho, and the integrin signaling. LRP-1 signaling plays an important role in the regulation of diverse cellular process, such as cell proliferation, survival, motility, differentiation, and transdifferentiation, and thus participates in the pathogenesis of organ dysfunction and injury. In this review, we focus on the current understanding of LRP-1 signaling and its roles in the development and progression of kidney disease. The role and signaling of LRP-1 in the nervous and cardiovascular systems, as well as in carcinogenesis, are also briefly discussed. MDPI 2014-12-10 /pmc/articles/PMC4284744/ /pubmed/25514242 http://dx.doi.org/10.3390/ijms151222887 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lin, Ling Hu, Kebin LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases |
title | LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases |
title_full | LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases |
title_fullStr | LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases |
title_full_unstemmed | LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases |
title_short | LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases |
title_sort | lrp-1: functions, signaling and implications in kidney and other diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284744/ https://www.ncbi.nlm.nih.gov/pubmed/25514242 http://dx.doi.org/10.3390/ijms151222887 |
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