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LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases

Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases....

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Detalles Bibliográficos
Autores principales: Lin, Ling, Hu, Kebin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284744/
https://www.ncbi.nlm.nih.gov/pubmed/25514242
http://dx.doi.org/10.3390/ijms151222887
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author Lin, Ling
Hu, Kebin
author_facet Lin, Ling
Hu, Kebin
author_sort Lin, Ling
collection PubMed
description Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases. In addition to its function as a scavenger receptor for various ligands, LRP-1 has been shown to transduce multiple intracellular signal pathways including mitogen-activated protein kinase (MAPK), Akt, Rho, and the integrin signaling. LRP-1 signaling plays an important role in the regulation of diverse cellular process, such as cell proliferation, survival, motility, differentiation, and transdifferentiation, and thus participates in the pathogenesis of organ dysfunction and injury. In this review, we focus on the current understanding of LRP-1 signaling and its roles in the development and progression of kidney disease. The role and signaling of LRP-1 in the nervous and cardiovascular systems, as well as in carcinogenesis, are also briefly discussed.
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spelling pubmed-42847442015-01-21 LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases Lin, Ling Hu, Kebin Int J Mol Sci Review Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases. In addition to its function as a scavenger receptor for various ligands, LRP-1 has been shown to transduce multiple intracellular signal pathways including mitogen-activated protein kinase (MAPK), Akt, Rho, and the integrin signaling. LRP-1 signaling plays an important role in the regulation of diverse cellular process, such as cell proliferation, survival, motility, differentiation, and transdifferentiation, and thus participates in the pathogenesis of organ dysfunction and injury. In this review, we focus on the current understanding of LRP-1 signaling and its roles in the development and progression of kidney disease. The role and signaling of LRP-1 in the nervous and cardiovascular systems, as well as in carcinogenesis, are also briefly discussed. MDPI 2014-12-10 /pmc/articles/PMC4284744/ /pubmed/25514242 http://dx.doi.org/10.3390/ijms151222887 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Ling
Hu, Kebin
LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
title LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
title_full LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
title_fullStr LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
title_full_unstemmed LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
title_short LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
title_sort lrp-1: functions, signaling and implications in kidney and other diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284744/
https://www.ncbi.nlm.nih.gov/pubmed/25514242
http://dx.doi.org/10.3390/ijms151222887
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