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Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in industrialized countries. The increasing prevalence of NAFLD mirrors the outbreak of obesity in western countries, highlighting the connection between these two conditions. Nevertheless, there is currently...

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Autores principales: Arias-Loste, María Teresa, Ranchal, Isidora, Romero-Gómez, Manuel, Crespo, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284758/
https://www.ncbi.nlm.nih.gov/pubmed/25514415
http://dx.doi.org/10.3390/ijms151223163
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author Arias-Loste, María Teresa
Ranchal, Isidora
Romero-Gómez, Manuel
Crespo, Javier
author_facet Arias-Loste, María Teresa
Ranchal, Isidora
Romero-Gómez, Manuel
Crespo, Javier
author_sort Arias-Loste, María Teresa
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in industrialized countries. The increasing prevalence of NAFLD mirrors the outbreak of obesity in western countries, highlighting the connection between these two conditions. Nevertheless, there is currently no specific pharmacotherapy for its treatment. Accepted management begins with weight loss and exercise. Moreover, exercise can provide metabolic benefits independently of weight loss. It is known how long-term aerobic training produces improvements in hepatic triglycerides, visceral adipose tissue and free fatty acids, even if there is no weight reduction. A recent study from Boström et al. unravels a potential molecular mechanism that may explain how exercise, independently of weight loss, can potentially improve metabolic parameters through a new messenger system (irisin) linking muscle and fat tissue. Irisin has been proposed to act as a hormone on subcutaneous white fat cells increasing energy expenditure by means of a program of brown-fat-like development. Moreover, it was also shown that irisin plasma concentration was higher in people who exercise, suggesting a molecular mechanism by which exercise may improve metabolism. The present systematic review is based on the possibility that irisin might represent a hypothetical connection between NAFLD pathogenesis and disease progression.
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spelling pubmed-42847582015-01-21 Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance Arias-Loste, María Teresa Ranchal, Isidora Romero-Gómez, Manuel Crespo, Javier Int J Mol Sci Review Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in industrialized countries. The increasing prevalence of NAFLD mirrors the outbreak of obesity in western countries, highlighting the connection between these two conditions. Nevertheless, there is currently no specific pharmacotherapy for its treatment. Accepted management begins with weight loss and exercise. Moreover, exercise can provide metabolic benefits independently of weight loss. It is known how long-term aerobic training produces improvements in hepatic triglycerides, visceral adipose tissue and free fatty acids, even if there is no weight reduction. A recent study from Boström et al. unravels a potential molecular mechanism that may explain how exercise, independently of weight loss, can potentially improve metabolic parameters through a new messenger system (irisin) linking muscle and fat tissue. Irisin has been proposed to act as a hormone on subcutaneous white fat cells increasing energy expenditure by means of a program of brown-fat-like development. Moreover, it was also shown that irisin plasma concentration was higher in people who exercise, suggesting a molecular mechanism by which exercise may improve metabolism. The present systematic review is based on the possibility that irisin might represent a hypothetical connection between NAFLD pathogenesis and disease progression. MDPI 2014-12-12 /pmc/articles/PMC4284758/ /pubmed/25514415 http://dx.doi.org/10.3390/ijms151223163 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Arias-Loste, María Teresa
Ranchal, Isidora
Romero-Gómez, Manuel
Crespo, Javier
Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance
title Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance
title_full Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance
title_fullStr Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance
title_full_unstemmed Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance
title_short Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance
title_sort irisin, a link among fatty liver disease, physical inactivity and insulin resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284758/
https://www.ncbi.nlm.nih.gov/pubmed/25514415
http://dx.doi.org/10.3390/ijms151223163
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