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P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System
Purinergic signalling plays a crucial role in proper functioning of the nervous system. Mechanisms depending on extracellular nucleotides and their P2 receptors also underlie a number of nervous system dysfunctions. This review aims to present the role of purinergic signalling, with particular focus...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284787/ https://www.ncbi.nlm.nih.gov/pubmed/25530618 http://dx.doi.org/10.3390/ijms151223672 |
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author | Puchałowicz, Kamila Tarnowski, Maciej Baranowska-Bosiacka, Irena Chlubek, Dariusz Dziedziejko, Violetta |
author_facet | Puchałowicz, Kamila Tarnowski, Maciej Baranowska-Bosiacka, Irena Chlubek, Dariusz Dziedziejko, Violetta |
author_sort | Puchałowicz, Kamila |
collection | PubMed |
description | Purinergic signalling plays a crucial role in proper functioning of the nervous system. Mechanisms depending on extracellular nucleotides and their P2 receptors also underlie a number of nervous system dysfunctions. This review aims to present the role of purinergic signalling, with particular focus devoted to role of P2 family receptors, in epilepsy, depression, neuropathic pain, nervous system neoplasms, such as glioma and neuroblastoma, neurodegenerative diseases like Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The above-mentioned conditions are associated with changes in expression of extracellular ectonucleotidases, P2X and P2Y receptors in neurons and glial cells, as well as releasing considerable amounts of nucleotides from activated or damaged nervous tissue cells into the extracellular space, which contributes to disturbance in purinergic signalling. The numerous studies indicate a potential possibility of using synthetic agonists/antagonists of P2 receptors in treatment of selected nervous system diseases. This is of particular significance, since numerous available agents reveal a low effectiveness and often produce side effects. |
format | Online Article Text |
id | pubmed-4284787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42847872015-01-21 P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System Puchałowicz, Kamila Tarnowski, Maciej Baranowska-Bosiacka, Irena Chlubek, Dariusz Dziedziejko, Violetta Int J Mol Sci Review Purinergic signalling plays a crucial role in proper functioning of the nervous system. Mechanisms depending on extracellular nucleotides and their P2 receptors also underlie a number of nervous system dysfunctions. This review aims to present the role of purinergic signalling, with particular focus devoted to role of P2 family receptors, in epilepsy, depression, neuropathic pain, nervous system neoplasms, such as glioma and neuroblastoma, neurodegenerative diseases like Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The above-mentioned conditions are associated with changes in expression of extracellular ectonucleotidases, P2X and P2Y receptors in neurons and glial cells, as well as releasing considerable amounts of nucleotides from activated or damaged nervous tissue cells into the extracellular space, which contributes to disturbance in purinergic signalling. The numerous studies indicate a potential possibility of using synthetic agonists/antagonists of P2 receptors in treatment of selected nervous system diseases. This is of particular significance, since numerous available agents reveal a low effectiveness and often produce side effects. MDPI 2014-12-18 /pmc/articles/PMC4284787/ /pubmed/25530618 http://dx.doi.org/10.3390/ijms151223672 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Puchałowicz, Kamila Tarnowski, Maciej Baranowska-Bosiacka, Irena Chlubek, Dariusz Dziedziejko, Violetta P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System |
title | P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System |
title_full | P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System |
title_fullStr | P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System |
title_full_unstemmed | P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System |
title_short | P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System |
title_sort | p2x and p2y receptors—role in the pathophysiology of the nervous system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284787/ https://www.ncbi.nlm.nih.gov/pubmed/25530618 http://dx.doi.org/10.3390/ijms151223672 |
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