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DNA binding reduces the dissociation rate of STAT1 dimers and impairs the interdimeric exchange of protomers

BACKGROUND: A shift between two dimer conformations has been proposed for the transcription factor STAT1 (signal transducer and activator of transcription 1) which links DNA binding of the parallel dimer to tyrosine dephosphorylation of the antiparallel dimer as two consecutive and important steps i...

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Detalles Bibliográficos
Autores principales:	Riebeling, Theresa, Staab, Julia, Herrmann-Lingen, Christoph, Meyer, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284922/ https://www.ncbi.nlm.nih.gov/pubmed/25526807 http://dx.doi.org/10.1186/s12858-014-0028-z

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