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Sleep Disordered Breathing in Children with Mitochondrial Disease
A retrospective chart review study was performed to determine the presence of sleep disordered breathing (SDB) in children with primary mitochondrial disease (MD). The symptoms, sleep-related breathing, and movement abnormalities are described for 18 subjects (ages 1.5 to 18 years, 61% male) with MD...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284925/ https://www.ncbi.nlm.nih.gov/pubmed/25587443 http://dx.doi.org/10.1155/2014/467576 |
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author | Mosquera, Ricardo A. Koenig, Mary Kay Adejumo, Rahmat B. Chevallier, Justyna Hashmi, S. Shahrukh Mitchell, Sarah E. Pacheco, Susan E. Jon, Cindy |
author_facet | Mosquera, Ricardo A. Koenig, Mary Kay Adejumo, Rahmat B. Chevallier, Justyna Hashmi, S. Shahrukh Mitchell, Sarah E. Pacheco, Susan E. Jon, Cindy |
author_sort | Mosquera, Ricardo A. |
collection | PubMed |
description | A retrospective chart review study was performed to determine the presence of sleep disordered breathing (SDB) in children with primary mitochondrial disease (MD). The symptoms, sleep-related breathing, and movement abnormalities are described for 18 subjects (ages 1.5 to 18 years, 61% male) with MD who underwent polysomnography in our pediatric sleep center from 2007 to 2012. Of the 18 subjects with MD, the common indications for polysomnography were excessive somnolence or fatigue (61%, N = 11), snoring (44%, N = 8), and sleep movement complaints (17%, N = 3). Polysomnographic measurements showed SDB in 56% (N = 10) (obstructive sleep apnea in 60% (N = 6), hypoxemia in 40% (N = 4), and sleep hypoventilation in 20% (N = 2)). There was a significant association between decreased muscle tone and SDB (P: 0.043) as well as obese and overweight status with SDB (P = 0.036). SDB is common in subjects with MD. Early detection of SDB, utilizing polysomnography, should be considered to assist in identification of MD patients who may benefit from sleep-related interventions. |
format | Online Article Text |
id | pubmed-4284925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42849252015-01-13 Sleep Disordered Breathing in Children with Mitochondrial Disease Mosquera, Ricardo A. Koenig, Mary Kay Adejumo, Rahmat B. Chevallier, Justyna Hashmi, S. Shahrukh Mitchell, Sarah E. Pacheco, Susan E. Jon, Cindy Pulm Med Research Article A retrospective chart review study was performed to determine the presence of sleep disordered breathing (SDB) in children with primary mitochondrial disease (MD). The symptoms, sleep-related breathing, and movement abnormalities are described for 18 subjects (ages 1.5 to 18 years, 61% male) with MD who underwent polysomnography in our pediatric sleep center from 2007 to 2012. Of the 18 subjects with MD, the common indications for polysomnography were excessive somnolence or fatigue (61%, N = 11), snoring (44%, N = 8), and sleep movement complaints (17%, N = 3). Polysomnographic measurements showed SDB in 56% (N = 10) (obstructive sleep apnea in 60% (N = 6), hypoxemia in 40% (N = 4), and sleep hypoventilation in 20% (N = 2)). There was a significant association between decreased muscle tone and SDB (P: 0.043) as well as obese and overweight status with SDB (P = 0.036). SDB is common in subjects with MD. Early detection of SDB, utilizing polysomnography, should be considered to assist in identification of MD patients who may benefit from sleep-related interventions. Hindawi Publishing Corporation 2014 2014-12-23 /pmc/articles/PMC4284925/ /pubmed/25587443 http://dx.doi.org/10.1155/2014/467576 Text en Copyright © 2014 Ricardo A. Mosquera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mosquera, Ricardo A. Koenig, Mary Kay Adejumo, Rahmat B. Chevallier, Justyna Hashmi, S. Shahrukh Mitchell, Sarah E. Pacheco, Susan E. Jon, Cindy Sleep Disordered Breathing in Children with Mitochondrial Disease |
title | Sleep Disordered Breathing in Children with Mitochondrial Disease |
title_full | Sleep Disordered Breathing in Children with Mitochondrial Disease |
title_fullStr | Sleep Disordered Breathing in Children with Mitochondrial Disease |
title_full_unstemmed | Sleep Disordered Breathing in Children with Mitochondrial Disease |
title_short | Sleep Disordered Breathing in Children with Mitochondrial Disease |
title_sort | sleep disordered breathing in children with mitochondrial disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284925/ https://www.ncbi.nlm.nih.gov/pubmed/25587443 http://dx.doi.org/10.1155/2014/467576 |
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