Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis

Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (...

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Autores principales: Lee, Yu-Mi, Kim, Sun-Mi, Park, Su Jin, Lee, Sang-Oh, Choi, Sang-Ho, Kim, Yang Soo, Woo, Jun Hee, Kim, Sung-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285001/
https://www.ncbi.nlm.nih.gov/pubmed/25566404
http://dx.doi.org/10.3947/ic.2014.46.4.248
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author Lee, Yu-Mi
Kim, Sun-Mi
Park, Su Jin
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang Soo
Woo, Jun Hee
Kim, Sung-Han
author_facet Lee, Yu-Mi
Kim, Sun-Mi
Park, Su Jin
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang Soo
Woo, Jun Hee
Kim, Sung-Han
author_sort Lee, Yu-Mi
collection PubMed
description Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×10(5) PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×10(5) PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.
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spelling pubmed-42850012015-01-06 Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis Lee, Yu-Mi Kim, Sun-Mi Park, Su Jin Lee, Sang-Oh Choi, Sang-Ho Kim, Yang Soo Woo, Jun Hee Kim, Sung-Han Infect Chemother Brief Communication Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×10(5) PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×10(5) PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses. The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2014-12 2014-12-29 /pmc/articles/PMC4285001/ /pubmed/25566404 http://dx.doi.org/10.3947/ic.2014.46.4.248 Text en Copyright © 2014 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Lee, Yu-Mi
Kim, Sun-Mi
Park, Su Jin
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang Soo
Woo, Jun Hee
Kim, Sung-Han
Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis
title Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis
title_full Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis
title_fullStr Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis
title_full_unstemmed Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis
title_short Factors Associated with a Strong Response to the T-SPOT.TB in Patients with Extrapulmonary Tuberculosis
title_sort factors associated with a strong response to the t-spot.tb in patients with extrapulmonary tuberculosis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285001/
https://www.ncbi.nlm.nih.gov/pubmed/25566404
http://dx.doi.org/10.3947/ic.2014.46.4.248
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