Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)

In utero hematopoietic stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenital hematopoietic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potentia...

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Detalles Bibliográficos
Autores principales: Loewendorf, Andrea I., Csete, Marie, Flake, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285014/
https://www.ncbi.nlm.nih.gov/pubmed/25610396
http://dx.doi.org/10.3389/fphar.2014.00282
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author Loewendorf, Andrea I.
Csete, Marie
Flake, Alan
author_facet Loewendorf, Andrea I.
Csete, Marie
Flake, Alan
author_sort Loewendorf, Andrea I.
collection PubMed
description In utero hematopoietic stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenital hematopoietic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potential immunological hurdles for the long-term establishment of chimerism and discuss relevant models and findings from both postnatal hematopoietic stem cell transplantation and IUHCT.
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spelling pubmed-42850142015-01-21 Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT) Loewendorf, Andrea I. Csete, Marie Flake, Alan Front Pharmacol Pharmacology In utero hematopoietic stem cell transplantation (IUHCT) is an attractive approach and a potentially curative surgery for several congenital hematopoietic diseases. In practice, this application has succeeded only in the context of Severe Combined Immunodeficiency Disorders. Here, we review potential immunological hurdles for the long-term establishment of chimerism and discuss relevant models and findings from both postnatal hematopoietic stem cell transplantation and IUHCT. Frontiers Media S.A. 2015-01-06 /pmc/articles/PMC4285014/ /pubmed/25610396 http://dx.doi.org/10.3389/fphar.2014.00282 Text en Copyright © 2015 Loewendorf, Csete and Flake. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Loewendorf, Andrea I.
Csete, Marie
Flake, Alan
Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)
title Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)
title_full Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)
title_fullStr Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)
title_full_unstemmed Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)
title_short Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)
title_sort immunological considerations in in utero hematopoetic stem cell transplantation (iuhct)
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285014/
https://www.ncbi.nlm.nih.gov/pubmed/25610396
http://dx.doi.org/10.3389/fphar.2014.00282
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