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Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease

BACKGROUND: Metabolic syndrome (MetS) is a condition characterized by a cluster of metabolic disorders and is associated with increased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the impact of MetS on CVD. METHODS: A total of 8,8...

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Autores principales: Suh, Sunghwan, Baek, Jongha, Bae, Ji Cheol, Kim, Kyoung-Nyoun, Park, Mi Kyoung, Kim, Duk Kyu, Cho, Nam H., Lee, Moon-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285030/
https://www.ncbi.nlm.nih.gov/pubmed/25559575
http://dx.doi.org/10.3803/EnM.2014.29.4.522
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author Suh, Sunghwan
Baek, Jongha
Bae, Ji Cheol
Kim, Kyoung-Nyoun
Park, Mi Kyoung
Kim, Duk Kyu
Cho, Nam H.
Lee, Moon-Kyu
author_facet Suh, Sunghwan
Baek, Jongha
Bae, Ji Cheol
Kim, Kyoung-Nyoun
Park, Mi Kyoung
Kim, Duk Kyu
Cho, Nam H.
Lee, Moon-Kyu
author_sort Suh, Sunghwan
collection PubMed
description BACKGROUND: Metabolic syndrome (MetS) is a condition characterized by a cluster of metabolic disorders and is associated with increased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the impact of MetS on CVD. METHODS: A total of 8,898 subjects (4,241 males and 4,657 females), 40 to 69 years of age, were enrolled and evaluated for the development of new onset CVD from 2001 to 2012 (median 8.1 years of follow-up). RESULTS: The prevalence of MetS at baseline was 22.0% (932/4,241) and 29.7% (1,383/4,657) in males and females, respectively. MetS was associated with increased risk of coronary heart disease (CHD; hazard ratio [HR], 1.818; 95% confidence interval [CI], 1.312 to 2.520 in males; HR, 1.789; 95% CI, 1.332 to 2.404 in females) and CVD (HR, 1.689; 95% CI, 1.295 to 2.204 in males; HR, 1.686; 95% CI, 1.007 to 2.192 in females). Specifically, MetS was associated with risk of future stroke in females only (HR, 1.486; 95% CI, 1.007 to 2.192). Among MetS components, abdominal obesity and hypertension were independent predictors of both CHD and CVD. In addition, a higher number of MetS components correlated with higher CVD risk. CONCLUSION: MetS is a significant risk factor for the development of CVD although its impact varies between sexes.
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spelling pubmed-42850302015-01-06 Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease Suh, Sunghwan Baek, Jongha Bae, Ji Cheol Kim, Kyoung-Nyoun Park, Mi Kyoung Kim, Duk Kyu Cho, Nam H. Lee, Moon-Kyu Endocrinol Metab (Seoul) Original Article BACKGROUND: Metabolic syndrome (MetS) is a condition characterized by a cluster of metabolic disorders and is associated with increased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the impact of MetS on CVD. METHODS: A total of 8,898 subjects (4,241 males and 4,657 females), 40 to 69 years of age, were enrolled and evaluated for the development of new onset CVD from 2001 to 2012 (median 8.1 years of follow-up). RESULTS: The prevalence of MetS at baseline was 22.0% (932/4,241) and 29.7% (1,383/4,657) in males and females, respectively. MetS was associated with increased risk of coronary heart disease (CHD; hazard ratio [HR], 1.818; 95% confidence interval [CI], 1.312 to 2.520 in males; HR, 1.789; 95% CI, 1.332 to 2.404 in females) and CVD (HR, 1.689; 95% CI, 1.295 to 2.204 in males; HR, 1.686; 95% CI, 1.007 to 2.192 in females). Specifically, MetS was associated with risk of future stroke in females only (HR, 1.486; 95% CI, 1.007 to 2.192). Among MetS components, abdominal obesity and hypertension were independent predictors of both CHD and CVD. In addition, a higher number of MetS components correlated with higher CVD risk. CONCLUSION: MetS is a significant risk factor for the development of CVD although its impact varies between sexes. Korean Endocrine Society 2014-12 2014-12-29 /pmc/articles/PMC4285030/ /pubmed/25559575 http://dx.doi.org/10.3803/EnM.2014.29.4.522 Text en Copyright © 2014 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Suh, Sunghwan
Baek, Jongha
Bae, Ji Cheol
Kim, Kyoung-Nyoun
Park, Mi Kyoung
Kim, Duk Kyu
Cho, Nam H.
Lee, Moon-Kyu
Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
title Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
title_full Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
title_fullStr Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
title_full_unstemmed Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
title_short Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
title_sort sex factors in the metabolic syndrome as a predictor of cardiovascular disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285030/
https://www.ncbi.nlm.nih.gov/pubmed/25559575
http://dx.doi.org/10.3803/EnM.2014.29.4.522
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