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Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly

BACKGROUND: The aim of this study was to assess the clinical differences between acromegalic patients with microadenoma and patients with macroadenoma, and to evaluate the predictive value of growth hormone (GH) levels for early detection of macroadenoma. METHODS: We performed a retrospective analys...

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Autores principales: Park, Ji Young, Kim, Jae Hyeon, Kim, Sun Wook, Chung, Jae Hoon, Min, Yong-Ki, Lee, Myung-Shik, Lee, Moon-Kyu, Kim, Kwang-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Endocrine Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285038/
https://www.ncbi.nlm.nih.gov/pubmed/25325263
http://dx.doi.org/10.3803/EnM.2014.29.4.450
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author Park, Ji Young
Kim, Jae Hyeon
Kim, Sun Wook
Chung, Jae Hoon
Min, Yong-Ki
Lee, Myung-Shik
Lee, Moon-Kyu
Kim, Kwang-Won
author_facet Park, Ji Young
Kim, Jae Hyeon
Kim, Sun Wook
Chung, Jae Hoon
Min, Yong-Ki
Lee, Myung-Shik
Lee, Moon-Kyu
Kim, Kwang-Won
author_sort Park, Ji Young
collection PubMed
description BACKGROUND: The aim of this study was to assess the clinical differences between acromegalic patients with microadenoma and patients with macroadenoma, and to evaluate the predictive value of growth hormone (GH) levels for early detection of macroadenoma. METHODS: We performed a retrospective analysis of 215 patients diagnosed with a GH-secreting pituitary adenoma. The patients were divided into two groups: the microadenoma group and the macroadenoma group, and the clinical parameters were compared between these two groups. The most sensitive and specific GH values for predicting macroadenoma were selected using receiver operating characteristic (ROC) curves. RESULTS: Compared with the microadenoma group, the macroadenoma group had a significantly younger age, higher body mass index, higher prevalence of hyperprolactinemia and hypogonadism, and a lower proportion of positive suppression to octreotide. However, there were no significant differences in the gender or in the prevalence of diabetes between the two groups. The tumor diameter was positively correlated with all GH values during the oral glucose tolerance test (OGTT). All GH values were significantly higher in the macroadenoma group than the microadenoma group. Cut-off values for GH levels at 0, 30, 60, 90, and 120 minutes for optimal discrimination between macroadenoma and microadenoma were 5.6, 5.7, 6.3, 6.0, and 5.8 ng/mL, respectively. ROC curve analysis revealed that the GH value at 30 minutes had the highest area under the curve. CONCLUSION: The GH level of 5.7 ng/mL or higher at 30 minutes during OGTT could provide sufficient information to detect macroadenoma at the time of diagnosis.
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spelling pubmed-42850382015-01-06 Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly Park, Ji Young Kim, Jae Hyeon Kim, Sun Wook Chung, Jae Hoon Min, Yong-Ki Lee, Myung-Shik Lee, Moon-Kyu Kim, Kwang-Won Endocrinol Metab (Seoul) Original Article BACKGROUND: The aim of this study was to assess the clinical differences between acromegalic patients with microadenoma and patients with macroadenoma, and to evaluate the predictive value of growth hormone (GH) levels for early detection of macroadenoma. METHODS: We performed a retrospective analysis of 215 patients diagnosed with a GH-secreting pituitary adenoma. The patients were divided into two groups: the microadenoma group and the macroadenoma group, and the clinical parameters were compared between these two groups. The most sensitive and specific GH values for predicting macroadenoma were selected using receiver operating characteristic (ROC) curves. RESULTS: Compared with the microadenoma group, the macroadenoma group had a significantly younger age, higher body mass index, higher prevalence of hyperprolactinemia and hypogonadism, and a lower proportion of positive suppression to octreotide. However, there were no significant differences in the gender or in the prevalence of diabetes between the two groups. The tumor diameter was positively correlated with all GH values during the oral glucose tolerance test (OGTT). All GH values were significantly higher in the macroadenoma group than the microadenoma group. Cut-off values for GH levels at 0, 30, 60, 90, and 120 minutes for optimal discrimination between macroadenoma and microadenoma were 5.6, 5.7, 6.3, 6.0, and 5.8 ng/mL, respectively. ROC curve analysis revealed that the GH value at 30 minutes had the highest area under the curve. CONCLUSION: The GH level of 5.7 ng/mL or higher at 30 minutes during OGTT could provide sufficient information to detect macroadenoma at the time of diagnosis. Korean Endocrine Society 2014-12 2014-12-29 /pmc/articles/PMC4285038/ /pubmed/25325263 http://dx.doi.org/10.3803/EnM.2014.29.4.450 Text en Copyright © 2014 Korean Endocrine Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Ji Young
Kim, Jae Hyeon
Kim, Sun Wook
Chung, Jae Hoon
Min, Yong-Ki
Lee, Myung-Shik
Lee, Moon-Kyu
Kim, Kwang-Won
Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly
title Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly
title_full Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly
title_fullStr Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly
title_full_unstemmed Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly
title_short Using Growth Hormone Levels to Detect Macroadenoma in Patients with Acromegaly
title_sort using growth hormone levels to detect macroadenoma in patients with acromegaly
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285038/
https://www.ncbi.nlm.nih.gov/pubmed/25325263
http://dx.doi.org/10.3803/EnM.2014.29.4.450
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