New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

Sonic Hedgehog protein (Shh) is a morphogen molecule important in embryonic development and in the progression of many cancer types in which it is aberrantly overexpressed. Fully mature Shh requires attachment of cholesterol and palmitic acid to its C- and N-termini, respectively. The study of lipid...

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Detalles Bibliográficos
Autores principales: Ciepla, Paulina, Konitsiotis, Antonios D., Serwa, Remigiusz A., Masumoto, Naoko, Leong, Wai P., Dallman, Margaret J., Magee, Anthony I., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285107/
https://www.ncbi.nlm.nih.gov/pubmed/25574372
http://dx.doi.org/10.1039/c4sc01600a

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