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Complex regulation of γ-secretase: from obligatory to modulatory subunits

γ-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form amyloid plaques, which contribute to Alzheimer’s disease (AD) pathogenesis. γ-Secretase also cleaves Notch, among many other type...

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Detalles Bibliográficos
Autores principales:	Gertsik, Natalya, Chiu, Danica, Li, Yue-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285130/ https://www.ncbi.nlm.nih.gov/pubmed/25610395 http://dx.doi.org/10.3389/fnagi.2014.00342

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