Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons

Several studies using vertebrate and invertebrate animal models have shown aging associated changes in brain function. Importantly, changes in soma size, loss or regression of dendrites and dendritic spines and alterations in the expression of neurotransmitter receptors in specific neurons were desc...

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Autores principales: Rizzo, Valerio, Richman, Jeffrey, Puthanveettil, Sathyanarayanan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285138/
https://www.ncbi.nlm.nih.gov/pubmed/25610394
http://dx.doi.org/10.3389/fnagi.2014.00337
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author Rizzo, Valerio
Richman, Jeffrey
Puthanveettil, Sathyanarayanan V.
author_facet Rizzo, Valerio
Richman, Jeffrey
Puthanveettil, Sathyanarayanan V.
author_sort Rizzo, Valerio
collection PubMed
description Several studies using vertebrate and invertebrate animal models have shown aging associated changes in brain function. Importantly, changes in soma size, loss or regression of dendrites and dendritic spines and alterations in the expression of neurotransmitter receptors in specific neurons were described. Despite this understanding, how aging impacts intrinsic properties of individual neurons or circuits that govern a defined behavior is yet to be determined. Here we discuss current understanding of specific electrophysiological changes in individual neurons and circuits during aging.
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spelling pubmed-42851382015-01-21 Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons Rizzo, Valerio Richman, Jeffrey Puthanveettil, Sathyanarayanan V. Front Aging Neurosci Neuroscience Several studies using vertebrate and invertebrate animal models have shown aging associated changes in brain function. Importantly, changes in soma size, loss or regression of dendrites and dendritic spines and alterations in the expression of neurotransmitter receptors in specific neurons were described. Despite this understanding, how aging impacts intrinsic properties of individual neurons or circuits that govern a defined behavior is yet to be determined. Here we discuss current understanding of specific electrophysiological changes in individual neurons and circuits during aging. Frontiers Media S.A. 2015-01-06 /pmc/articles/PMC4285138/ /pubmed/25610394 http://dx.doi.org/10.3389/fnagi.2014.00337 Text en Copyright © 2015 Rizzo, Richman and Puthanveettil. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rizzo, Valerio
Richman, Jeffrey
Puthanveettil, Sathyanarayanan V.
Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons
title Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons
title_full Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons
title_fullStr Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons
title_full_unstemmed Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons
title_short Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons
title_sort dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285138/
https://www.ncbi.nlm.nih.gov/pubmed/25610394
http://dx.doi.org/10.3389/fnagi.2014.00337
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