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Mechanisms of Myofascial Pain

Myofascial pain syndrome is an important health problem. It affects a majority of the general population, impairs mobility, causes pain, and reduces the overall sense of well-being. Underlying this syndrome is the existence of painful taut bands of muscle that contain discrete, hypersensitive foci c...

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Detalles Bibliográficos
Autor principal: Jafri, M. Saleet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285362/
https://www.ncbi.nlm.nih.gov/pubmed/25574501
http://dx.doi.org/10.1155/2014/523924
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author Jafri, M. Saleet
author_facet Jafri, M. Saleet
author_sort Jafri, M. Saleet
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description Myofascial pain syndrome is an important health problem. It affects a majority of the general population, impairs mobility, causes pain, and reduces the overall sense of well-being. Underlying this syndrome is the existence of painful taut bands of muscle that contain discrete, hypersensitive foci called myofascial trigger points. In spite of the significant impact on public health, a clear mechanistic understanding of the disorder does not exist. This is likely due to the complex nature of the disorder which involves the integration of cellular signaling, excitation-contraction coupling, neuromuscular inputs, local circulation, and energy metabolism. The difficulties are further exacerbated by the lack of an animal model for myofascial pain to test mechanistic hypothesis. In this review, current theories for myofascial pain are presented and their relative strengths and weaknesses are discussed. Based on new findings linking mechanoactivation of reactive oxygen species signaling to destabilized calcium signaling, we put forth a novel mechanistic hypothesis for the initiation and maintenance of myofascial trigger points. It is hoped that this lays a new foundation for understanding myofascial pain syndrome and how current therapies work, and gives key insights that will lead to the improvement of therapies for its treatment.
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spelling pubmed-42853622015-01-06 Mechanisms of Myofascial Pain Jafri, M. Saleet Int Sch Res Notices Review Article Myofascial pain syndrome is an important health problem. It affects a majority of the general population, impairs mobility, causes pain, and reduces the overall sense of well-being. Underlying this syndrome is the existence of painful taut bands of muscle that contain discrete, hypersensitive foci called myofascial trigger points. In spite of the significant impact on public health, a clear mechanistic understanding of the disorder does not exist. This is likely due to the complex nature of the disorder which involves the integration of cellular signaling, excitation-contraction coupling, neuromuscular inputs, local circulation, and energy metabolism. The difficulties are further exacerbated by the lack of an animal model for myofascial pain to test mechanistic hypothesis. In this review, current theories for myofascial pain are presented and their relative strengths and weaknesses are discussed. Based on new findings linking mechanoactivation of reactive oxygen species signaling to destabilized calcium signaling, we put forth a novel mechanistic hypothesis for the initiation and maintenance of myofascial trigger points. It is hoped that this lays a new foundation for understanding myofascial pain syndrome and how current therapies work, and gives key insights that will lead to the improvement of therapies for its treatment. Hindawi Publishing Corporation 2014-08-18 /pmc/articles/PMC4285362/ /pubmed/25574501 http://dx.doi.org/10.1155/2014/523924 Text en Copyright © 2014 M. Saleet Jafri. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jafri, M. Saleet
Mechanisms of Myofascial Pain
title Mechanisms of Myofascial Pain
title_full Mechanisms of Myofascial Pain
title_fullStr Mechanisms of Myofascial Pain
title_full_unstemmed Mechanisms of Myofascial Pain
title_short Mechanisms of Myofascial Pain
title_sort mechanisms of myofascial pain
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285362/
https://www.ncbi.nlm.nih.gov/pubmed/25574501
http://dx.doi.org/10.1155/2014/523924
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