Cargando…

The Selective Activation of p53 Target Genes Regulated by SMYD2 in BIX-01294 Induced Autophagy-Related Cell Death

Transcription regulation emerged to be one of the key mechanisms in regulating autophagy. Inhibitors of H3K9 methylation activates the expression of LC3B, as well as other autophagy-related genes, and promotes autophagy process. However, the detailed mechanisms of autophagy regulated by nuclear fact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Jia-Dong, Lei, Pin-Ji, Zheng, Jun-Yi, Wang, Xiang, Li, Shangze, Liu, Huan, He, Yi-Lei, Wang, Zhao-Ning, Wei, Gang, Zhang, Xiaodong, Li, Lian-Yun, Wu, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285553/ https://www.ncbi.nlm.nih.gov/pubmed/25562686 http://dx.doi.org/10.1371/journal.pone.0116782

Ejemplares similares

BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells
por: Ciechomska, Iwona Anna, et al.
Publicado: (2016)

BIX‐01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME‐mediated pyroptosis
por: Deng, Bei‐Bei, et al.
Publicado: (2020)

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
por: Chang, Yanqi, et al.
Publicado: (2009)

Mechanism of G9a inhibitor BIX-01294 acting on U251 glioma cells
por: Guo, Ai-Shun, et al.
Publicado: (2016)

The Histone Methyltransferase Inhibitor BIX01294 Inhibits HIF-1α Stability and Angiogenesis
por: Oh, Su Young, et al.
Publicado: (2015)

EHMT2 inhibitor BIX-01294 induces endoplasmic reticulum stress mediated apoptosis and autophagy in diffuse large B-cell lymphoma cells
por: Xu, Linyan, et al.
Publicado: (2021)

Effect of BIX-01294 on H3K9me2 levels and the imprinted gene Snrpn in mouse embryonic fibroblast cells
por: Chen, Peng, et al.
Publicado: (2015)

TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos
por: Cao, Zubing, et al.
Publicado: (2017)

Modulation of microRNA expression in human lung cancer cells by the G9a histone methyltransferase inhibitor BIX01294
por: PANG, ALAN LAP-YIN, et al.
Publicado: (2014)

Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity
por: Rotili, Dante, et al.
Publicado: (2014)

Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models
por: Chase, Kayla A., et al.
Publicado: (2019)

Inhibition of Histone H3K9 Methylation by BIX-01294 Promotes Stress-Induced Microspore Totipotency and Enhances Embryogenesis Initiation
por: Berenguer, Eduardo, et al.
Publicado: (2017)

The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Plasmodium falciparum Gametocyte Development and Transmission
por: Ngwa, Che Julius, et al.
Publicado: (2019)

BIX01294 inhibits EGFR signaling in EGFR-mutant lung adenocarcinoma cells through a BCKDHA-mediated reduction in the EGFR level
por: Kim, Ji Hye, et al.
Publicado: (2021)

BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression
por: Woo, Seon Min, et al.
Publicado: (2018)

Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide
por: Ciechomska, Iwona Anna, et al.
Publicado: (2018)

EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells
por: Cui, Jing, et al.
Publicado: (2015)

Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294
por: Samer, Sadia, et al.
Publicado: (2020)

Comparing The Effects of Small Molecules BIX-01294, Bay K8644, RG-108 and Valproic Acid, and Their Different Combinations on Induction of Pluripotency Marker-Genes by Oct4 in The Mouse Brain
por: Asadi, Sareh, et al.
Publicado: (2015)

Inhibition of SMYD2 Sensitized Cisplatin to Resistant Cells in NSCLC Through Activating p53 Pathway
por: Shang, Lei, et al.
Publicado: (2019)

Evaluation of performance for IBARAKI biological crystal diffractometer iBIX with new detectors
por: Kusaka, Katsuhiro, et al.
Publicado: (2013)

Histone methyltransferase Smyd3 is a new regulator for vascular senescence
por: Yang, Di, et al.
Publicado: (2020)

Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging
por: Yang, Di, et al.
Publicado: (2020)

Histone methyltransferase SMYD2: ubiquitous regulator of disease
por: Yi, Xin, et al.
Publicado: (2019)

Smyd2 conformational changes in response to p53 binding: role of the C‐terminal domain
por: Chandramouli, Balasubramanian, et al.
Publicado: (2019)

PathBIX—a web server for network-based pathway annotation with adaptive null models
por: Castresana-Aguirre, Miguel, et al.
Publicado: (2021)

ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells
por: Wang, Lei, et al.
Publicado: (2017)

SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis
por: Ye, Xiangli, et al.
Publicado: (2016)

Upregulation of SMYD3 and SMYD3 VNTR 3/3 polymorphism increase the risk of hepatocellular carcinoma
por: Binh, Mai Thanh, et al.
Publicado: (2020)

SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7
por: Wu, Lei, et al.
Publicado: (2021)

Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells
por: Wang, Sen, et al.
Publicado: (2017)

Zero-Dimensional Cs(3)BiX(6) (X = Br, Cl) Single Crystal Films with Second Harmonic Generation
por: Yao, Junjie, et al.
Publicado: (2022)

SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin
por: Li, Dali, et al.
Publicado: (2009)

New open conformation of SMYD3 implicates conformational selection and allostery
por: Spellmon, Nicholas, et al.
Publicado: (2016)

SMYD proteins in immunity: dawning of a new era
por: Doughan, Maysaa, et al.
Publicado: (2016)

Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice
por: Cui, Binbin, et al.
Publicado: (2022)

Cross-talk between CDK4/6 and SMYD2 regulates gene transcription, tubulin methylation, and ciliogenesis
por: Li, Linda Xiaoyan, et al.
Publicado: (2020)

Smyd1b is required for skeletal and cardiac muscle function in zebrafish
por: Li, Huiqing, et al.
Publicado: (2013)

Application of profile fitting method to neutron time-of-flight protein single crystal diffraction data collected at the iBIX
por: Yano, Naomine, et al.
Publicado: (2016)

SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression
por: Chen, Yun-Ju, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1pvp6srho5tr2olk7o5ii1q0h4