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Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats
BACKGROUND: Swietenia macrophylla King. (Meliaceae) seeds (SMS); commonly known as sky fruit and locally known in Malaysia as Tunjuk Langit; have been used in traditional Malay medicine for the treatment of diabetes and hypertension. The people eat only a tiny amount of raw seed, weighing not more t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285647/ https://www.ncbi.nlm.nih.gov/pubmed/25598633 http://dx.doi.org/10.4103/0974-8490.147197 |
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author | Balijepalli, Madhu Katyayani Suppaiah, Velan Chin, An-me Buru, Ayuba Sunday Sagineedu, Sreenivasa Rao Pichika, Mallikarjuna Rao |
author_facet | Balijepalli, Madhu Katyayani Suppaiah, Velan Chin, An-me Buru, Ayuba Sunday Sagineedu, Sreenivasa Rao Pichika, Mallikarjuna Rao |
author_sort | Balijepalli, Madhu Katyayani |
collection | PubMed |
description | BACKGROUND: Swietenia macrophylla King. (Meliaceae) seeds (SMS); commonly known as sky fruit and locally known in Malaysia as Tunjuk Langit; have been used in traditional Malay medicine for the treatment of diabetes and hypertension. The people eat only a tiny amount of raw seed, weighing not more than 5 mg. AIM: To evaluate the safety of Swietenia macrophylla seeds (SMS) at a single-dose oral administration of 2 g/kg body weight (bw) in sprague dawley (SD) rats. MATERIALS AND METHODS: Eight-week old male and female SD rats were administered a single-oral dose of 2g/kg bw. The rats’ general behavior, and toxic signs were observed throughout the 14-day study period. The food and water intake by rats and their body weight were monitored during the study period. At the end of the study period, the relative weights of the organs (lung, liver, spleen, heart, kidney, testis, stomach); the hematological and biochemical parameters were measured; the architecture and histology of the organs (liver, kidney and lungs) were observed. RESULTS: Oral administration of SMS to rats did not affect, either food or water intake; relative organ weight of vital organs; the hematological and biochemical parameters; did not show significant changes in the architecture and histology of vital organs. Overall, there were neither signs of toxicity nor deaths recorded during the study period. CONCLUSION: The rat dose of 2 g/kg bw is equivalent to the human dose of 325 mg/kg bw, which is well below the usual amount consumed by people, did not show any signs of toxicity in rats. |
format | Online Article Text |
id | pubmed-4285647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42856472015-01-16 Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats Balijepalli, Madhu Katyayani Suppaiah, Velan Chin, An-me Buru, Ayuba Sunday Sagineedu, Sreenivasa Rao Pichika, Mallikarjuna Rao Pharmacognosy Res Original Article BACKGROUND: Swietenia macrophylla King. (Meliaceae) seeds (SMS); commonly known as sky fruit and locally known in Malaysia as Tunjuk Langit; have been used in traditional Malay medicine for the treatment of diabetes and hypertension. The people eat only a tiny amount of raw seed, weighing not more than 5 mg. AIM: To evaluate the safety of Swietenia macrophylla seeds (SMS) at a single-dose oral administration of 2 g/kg body weight (bw) in sprague dawley (SD) rats. MATERIALS AND METHODS: Eight-week old male and female SD rats were administered a single-oral dose of 2g/kg bw. The rats’ general behavior, and toxic signs were observed throughout the 14-day study period. The food and water intake by rats and their body weight were monitored during the study period. At the end of the study period, the relative weights of the organs (lung, liver, spleen, heart, kidney, testis, stomach); the hematological and biochemical parameters were measured; the architecture and histology of the organs (liver, kidney and lungs) were observed. RESULTS: Oral administration of SMS to rats did not affect, either food or water intake; relative organ weight of vital organs; the hematological and biochemical parameters; did not show significant changes in the architecture and histology of vital organs. Overall, there were neither signs of toxicity nor deaths recorded during the study period. CONCLUSION: The rat dose of 2 g/kg bw is equivalent to the human dose of 325 mg/kg bw, which is well below the usual amount consumed by people, did not show any signs of toxicity in rats. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4285647/ /pubmed/25598633 http://dx.doi.org/10.4103/0974-8490.147197 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Balijepalli, Madhu Katyayani Suppaiah, Velan Chin, An-me Buru, Ayuba Sunday Sagineedu, Sreenivasa Rao Pichika, Mallikarjuna Rao Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats |
title | Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats |
title_full | Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats |
title_fullStr | Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats |
title_full_unstemmed | Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats |
title_short | Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats |
title_sort | acute oral toxicity studies of swietenia macrophylla seeds in sprague dawley rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285647/ https://www.ncbi.nlm.nih.gov/pubmed/25598633 http://dx.doi.org/10.4103/0974-8490.147197 |
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