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Cycloolivil, a lignan from the roots of Stereospermum suaveolens
BACKGROUND: Stereospermum suaveolens DC. (Syn. S. chelonoides) belonging to family Bignoniaceae is an important medicinal plant in India. Traditionally, it is mainly used as analgesic, liver stimulant, astringent, wound healing and antidyspeptic. Roots of this plant are one of the ingredients of Das...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285648/ https://www.ncbi.nlm.nih.gov/pubmed/25598634 http://dx.doi.org/10.4103/0974-8490.147198 |
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author | wahab Sab, B. Abdul Jacob, Janani Manjunath, Gururaja Giligar Singh, Vineet Kumar Mundkinajeedu, Deepak Shankarappa, Shashidhara |
author_facet | wahab Sab, B. Abdul Jacob, Janani Manjunath, Gururaja Giligar Singh, Vineet Kumar Mundkinajeedu, Deepak Shankarappa, Shashidhara |
author_sort | wahab Sab, B. Abdul |
collection | PubMed |
description | BACKGROUND: Stereospermum suaveolens DC. (Syn. S. chelonoides) belonging to family Bignoniaceae is an important medicinal plant in India. Traditionally, it is mainly used as analgesic, liver stimulant, astringent, wound healing and antidyspeptic. Roots of this plant are one of the ingredients of Dashamularishta. The plant has been studied for many pharmacological actions, only few were concerned with isolation of active compounds. OBJECTIVE: The present work deals with the isolation and identification of phytochemical constituents present in the roots of Stereospermum suaveolens. MATERIAL AND METHODS: The compounds were isolated from the ethyl acetate-soluble fraction from the methanol extract of S. suaveolens by using open silica gel column chromatography and HPLC was carried out for all the fractions to target the major peaks in fractions. RESULTS AND CONCLUSION: The isolated compounds structures were elucidated by analysis of spectroscopic data (UV, IR, 1D-NMR, and MS) and characterized as Cycloolivil (1) reported for the first time from this plant species, Lapachol (2) and β-sitosterol (3), respectively. |
format | Online Article Text |
id | pubmed-4285648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-42856482015-01-16 Cycloolivil, a lignan from the roots of Stereospermum suaveolens wahab Sab, B. Abdul Jacob, Janani Manjunath, Gururaja Giligar Singh, Vineet Kumar Mundkinajeedu, Deepak Shankarappa, Shashidhara Pharmacognosy Res Original Article BACKGROUND: Stereospermum suaveolens DC. (Syn. S. chelonoides) belonging to family Bignoniaceae is an important medicinal plant in India. Traditionally, it is mainly used as analgesic, liver stimulant, astringent, wound healing and antidyspeptic. Roots of this plant are one of the ingredients of Dashamularishta. The plant has been studied for many pharmacological actions, only few were concerned with isolation of active compounds. OBJECTIVE: The present work deals with the isolation and identification of phytochemical constituents present in the roots of Stereospermum suaveolens. MATERIAL AND METHODS: The compounds were isolated from the ethyl acetate-soluble fraction from the methanol extract of S. suaveolens by using open silica gel column chromatography and HPLC was carried out for all the fractions to target the major peaks in fractions. RESULTS AND CONCLUSION: The isolated compounds structures were elucidated by analysis of spectroscopic data (UV, IR, 1D-NMR, and MS) and characterized as Cycloolivil (1) reported for the first time from this plant species, Lapachol (2) and β-sitosterol (3), respectively. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4285648/ /pubmed/25598634 http://dx.doi.org/10.4103/0974-8490.147198 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article wahab Sab, B. Abdul Jacob, Janani Manjunath, Gururaja Giligar Singh, Vineet Kumar Mundkinajeedu, Deepak Shankarappa, Shashidhara Cycloolivil, a lignan from the roots of Stereospermum suaveolens |
title | Cycloolivil, a lignan from the roots of Stereospermum suaveolens |
title_full | Cycloolivil, a lignan from the roots of Stereospermum suaveolens |
title_fullStr | Cycloolivil, a lignan from the roots of Stereospermum suaveolens |
title_full_unstemmed | Cycloolivil, a lignan from the roots of Stereospermum suaveolens |
title_short | Cycloolivil, a lignan from the roots of Stereospermum suaveolens |
title_sort | cycloolivil, a lignan from the roots of stereospermum suaveolens |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285648/ https://www.ncbi.nlm.nih.gov/pubmed/25598634 http://dx.doi.org/10.4103/0974-8490.147198 |
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