Cargando…

Bone metastases and skeletal-related events from neuroendocrine tumors

Neuroendocrine tumors (NETs) metastasize to bone; however, a multi-institution evaluation of the natural history and complications of bone metastases across multiple NET subtypes has not, to our knowledge, previously been conducted. At two tertiary academic centers, we identified patients with bone...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Loon, Katherine, Zhang, Li, Keiser, Jennifer, Carrasco, Cendy, Glass, Katherine, Ramirez, Maria-Teresa, Bobiak, Sarah, Nakakura, Eric K, Venook, Alan P, Shah, Manisha H, Bergsland, Emily K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285767/
https://www.ncbi.nlm.nih.gov/pubmed/25430999
http://dx.doi.org/10.1530/EC-14-0119
_version_ 1782351594711416832
author Van Loon, Katherine
Zhang, Li
Keiser, Jennifer
Carrasco, Cendy
Glass, Katherine
Ramirez, Maria-Teresa
Bobiak, Sarah
Nakakura, Eric K
Venook, Alan P
Shah, Manisha H
Bergsland, Emily K
author_facet Van Loon, Katherine
Zhang, Li
Keiser, Jennifer
Carrasco, Cendy
Glass, Katherine
Ramirez, Maria-Teresa
Bobiak, Sarah
Nakakura, Eric K
Venook, Alan P
Shah, Manisha H
Bergsland, Emily K
author_sort Van Loon, Katherine
collection PubMed
description Neuroendocrine tumors (NETs) metastasize to bone; however, a multi-institution evaluation of the natural history and complications of bone metastases across multiple NET subtypes has not, to our knowledge, previously been conducted. At two tertiary academic centers, we identified patients with bone metastases from databases of patients with a diagnosis of NET between 2004 and 2008. Detection of bone metastases, occurrence of skeletal-related events (SREs), and interventions were analyzed using summary statistics and categorical methods. Time-to-event data were assessed using Kaplan–Meier estimates and log-rank tests. Between 2004 and 2008, 82 out of 691 NET patients (12%) were reported to have bone metastases. Of the 82 patients with bone metastases, 55% were men and their median age was 49. Bone metastases occurred in 25% of pheochromocytomas and paragangliomas, 20% of high-grade neuroendocrine carcinomas, 9% of carcinoid tumors, and 8% of pancreatic NETs. At time of detection of bone metastases, 60% reported symptoms, including pain; 10% developed cord compression, 9% suffered a pathological fracture, and 4% developed hypercalcemia. Occurrence of SREs did not differ significantly with regard to tumor histology. Of patients with bone metastases, 67 (82%) received at least one form of bone-directed treatment, 50% received radiation, 45% received a bisphosphonate, 18% underwent surgery, 11% received (131)I-MIBG, 5% received denosumab, and 46% were treated with more than one treatment modality. Bone metastases occur in a substantial number of patients diagnosed with NETs. Patients are often symptomatic and many develop SREs. Given the recent therapeutic advances and increasing life expectancy of patients with NETs, development of guidelines for surveillance and clinical care of bone metastases from NETs is needed.
format Online
Article
Text
id pubmed-4285767
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Bioscientifica Ltd
record_format MEDLINE/PubMed
spelling pubmed-42857672015-02-10 Bone metastases and skeletal-related events from neuroendocrine tumors Van Loon, Katherine Zhang, Li Keiser, Jennifer Carrasco, Cendy Glass, Katherine Ramirez, Maria-Teresa Bobiak, Sarah Nakakura, Eric K Venook, Alan P Shah, Manisha H Bergsland, Emily K Endocr Connect Research Neuroendocrine tumors (NETs) metastasize to bone; however, a multi-institution evaluation of the natural history and complications of bone metastases across multiple NET subtypes has not, to our knowledge, previously been conducted. At two tertiary academic centers, we identified patients with bone metastases from databases of patients with a diagnosis of NET between 2004 and 2008. Detection of bone metastases, occurrence of skeletal-related events (SREs), and interventions were analyzed using summary statistics and categorical methods. Time-to-event data were assessed using Kaplan–Meier estimates and log-rank tests. Between 2004 and 2008, 82 out of 691 NET patients (12%) were reported to have bone metastases. Of the 82 patients with bone metastases, 55% were men and their median age was 49. Bone metastases occurred in 25% of pheochromocytomas and paragangliomas, 20% of high-grade neuroendocrine carcinomas, 9% of carcinoid tumors, and 8% of pancreatic NETs. At time of detection of bone metastases, 60% reported symptoms, including pain; 10% developed cord compression, 9% suffered a pathological fracture, and 4% developed hypercalcemia. Occurrence of SREs did not differ significantly with regard to tumor histology. Of patients with bone metastases, 67 (82%) received at least one form of bone-directed treatment, 50% received radiation, 45% received a bisphosphonate, 18% underwent surgery, 11% received (131)I-MIBG, 5% received denosumab, and 46% were treated with more than one treatment modality. Bone metastases occur in a substantial number of patients diagnosed with NETs. Patients are often symptomatic and many develop SREs. Given the recent therapeutic advances and increasing life expectancy of patients with NETs, development of guidelines for surveillance and clinical care of bone metastases from NETs is needed. Bioscientifica Ltd 2015-01-07 /pmc/articles/PMC4285767/ /pubmed/25430999 http://dx.doi.org/10.1530/EC-14-0119 Text en © 2015 The authors http://creativecommons.org/licenses/by/3.0/deed.en_GB This work is licensed under a Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/deed.en_GB)
spellingShingle Research
Van Loon, Katherine
Zhang, Li
Keiser, Jennifer
Carrasco, Cendy
Glass, Katherine
Ramirez, Maria-Teresa
Bobiak, Sarah
Nakakura, Eric K
Venook, Alan P
Shah, Manisha H
Bergsland, Emily K
Bone metastases and skeletal-related events from neuroendocrine tumors
title Bone metastases and skeletal-related events from neuroendocrine tumors
title_full Bone metastases and skeletal-related events from neuroendocrine tumors
title_fullStr Bone metastases and skeletal-related events from neuroendocrine tumors
title_full_unstemmed Bone metastases and skeletal-related events from neuroendocrine tumors
title_short Bone metastases and skeletal-related events from neuroendocrine tumors
title_sort bone metastases and skeletal-related events from neuroendocrine tumors
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285767/
https://www.ncbi.nlm.nih.gov/pubmed/25430999
http://dx.doi.org/10.1530/EC-14-0119
work_keys_str_mv AT vanloonkatherine bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT zhangli bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT keiserjennifer bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT carrascocendy bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT glasskatherine bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT ramirezmariateresa bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT bobiaksarah bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT nakakuraerick bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT venookalanp bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT shahmanishah bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors
AT bergslandemilyk bonemetastasesandskeletalrelatedeventsfromneuroendocrinetumors