A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)

Mutations in TNFRSF1A encoding TNF receptor 1 (TNFR1) cause the autosomal dominant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory disorder. Misfolding, intracellular aggregation, and ligand-independent signaling by mutant TNFR1 are central to disease pathophysiology....

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Detalles Bibliográficos
Autores principales: Negm, Ola H, Mannsperger, Heiko A, McDermott, Elizabeth M, Drewe, Elizabeth, Powell, Richard J, Todd, Ian, Fairclough, Lucy C, Tighe, Patrick J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Innate Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285816/
https://www.ncbi.nlm.nih.gov/pubmed/24668260
http://dx.doi.org/10.1002/eji.201344328

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