Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?

Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic...

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Detalles Bibliográficos
Autores principales: Bates, Jennifer, Diehl, Lauri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2014
Materias:
Invited Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285849/
https://www.ncbi.nlm.nih.gov/pubmed/24122796
http://dx.doi.org/10.1002/path.4277
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author Bates, Jennifer
Diehl, Lauri
author_facet Bates, Jennifer
Diehl, Lauri
author_sort Bates, Jennifer
collection PubMed
description Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells in regulating response to gut microflora. We discuss areas of therapeutic opportunity in this evolving landscape. © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
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spelling pubmed-42858492015-01-27 Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity? Bates, Jennifer Diehl, Lauri J Pathol Invited Reviews Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells in regulating response to gut microflora. We discuss areas of therapeutic opportunity in this evolving landscape. © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. John Wiley & Sons, Ltd 2014-01 2013-12-10 /pmc/articles/PMC4285849/ /pubmed/24122796 http://dx.doi.org/10.1002/path.4277 Text en © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Invited Reviews
Bates, Jennifer
Diehl, Lauri
Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?
title Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?
title_full Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?
title_fullStr Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?
title_full_unstemmed Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?
title_short Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?
title_sort dendritic cells in ibd pathogenesis: an area of therapeutic opportunity?
topic Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285849/
https://www.ncbi.nlm.nih.gov/pubmed/24122796
http://dx.doi.org/10.1002/path.4277
work_keys_str_mv AT batesjennifer dendriticcellsinibdpathogenesisanareaoftherapeuticopportunity
AT diehllauri dendriticcellsinibdpathogenesisanareaoftherapeuticopportunity

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